ANCA-negative glomerulonephritis associated with nonasthmatic Churg-Strauss syndrome

Nature Clinical Practice. Nephrology
Asha J ChemmalakuzhyS Susan Hedayati

Abstract

A 36-year-old white male with a history of allergic rhinitis and sinusitis presented to the emergency room with abdominal pain and diarrhea. Physical examination revealed fever, hypoxemia and a maculopapular rash. Laboratory tests showed proteinuria, hematuria, leukocytosis, eosinophilia and an elevated erythrocyte sedimentation rate. Physical examination, urine and blood analysis and culture, chest radiography, chest and abdominal CT, esophagogastroduodenoscopy, skin and kidney biopsy, serology and renal ultrasound. Pauci-immune focal necrotizing glomerulonephritis with crescents and interstitial eosinophilia, consistent with Churg-Strauss syndrome. The patient was treated with methylprednisolone 1 g/day intravenously for 3 days. He also received oral clotrimazole and combined oral sulfamethoxazole and trimethoprim for prophylaxis against candidiasis and pneumonia, respectively. He left the hospital against medical advice and was lost to follow-up.

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Citations

May 11, 2010·Nephron. Clinical Practice·Giovani GadonskiDomingos O d'Avila
Jun 11, 2010·Indian Journal of Nephrology·K SampathkumarR N Ajeshkumar
Sep 30, 2021·The Journal of International Medical Research·Aleksandra KezićVišnja Ležaić

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