Ancestral experience as a game changer in stress vulnerability and disease outcomes

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Gerlinde A MetzDavid M Olson

Abstract

Stress is one of the most powerful experiences to influence health and disease. Through epigenetic mechanisms, stress may generate a footprint that propagates to subsequent generations. Programming by prenatal stress or adverse experience in parents, grandparents, or earlier generations may thus be a critical determinant of lifetime health trajectories. Changes in regulation of microRNAs (miRNAs) by stress may enhance the vulnerability to certain pathogenic factors. This review explores the hypothesis that miRNAs represent stress-responsive elements in epigenetic regulation that are potentially heritable. Recent findings suggest that miRNAs are key players linking adverse early environments or ancestral stress with disease risk, thus they represent useful predictive disease biomarkers. Since miRNA signatures of disease are potentially heritable, big data management platforms will be vital to harness multi-generational information and capture succinct yet potent biomarkers capable of directing preventative treatments. This feature would offer a unique window of opportunity to advance personalized medicine.

References

Sep 12, 2000·Current Hypertension Reports·Z PausovaP Hamet
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Jul 16, 2003·Molecular and Cellular Biology·Robert A Waterland, Randy L Jirtle
Nov 20, 2003·Biological Psychiatry·Christopher L CoeEberhard Fuchs
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·Bea R H Van den BerghLieven Lagae
Nov 24, 2005·Frontiers in Neuroendocrinology·Moshe SzyfMichael J Meaney
Jan 20, 2006·Nature·Gerhard M SchrattMichael E Greenberg
Aug 8, 2006·Annals of the New York Academy of Sciences·Sarah R BrandRachel Yehuda
Apr 21, 2007·Journal of Internal Medicine·D J P Barker
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bea R H Van den BerghLieven Lagae
Jun 15, 2007·Molecular Cell·John TsangAlexander van Oudenaarden
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
Aug 23, 2007·Physiological Genomics·Sadakatsu IkedaWilliam T Pu
Oct 24, 2007·Reproductive Toxicology·Michael K Skinner
Mar 4, 2008·Nature Structural & Molecular Biology·Lasse SinkkonenWitold Filipowicz
Mar 13, 2008·Anatomia, histologia, embryologia·C RaschkeG Jirikowski
Apr 17, 2008·The European Journal of Neuroscience·Lori K SmithGerlinde A Metz
Jul 30, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Daniel K Morgan, Emma Whitelaw
Jul 31, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·David P LaplanteSuzanne King
Aug 22, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·R C PainterT J Roseboom
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bridget R Mueller, Tracy L Bale
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Dec 24, 2008·Obstetrics and Gynecology·Iwa Antonow-SchlorkeMatthias Schwab
Jan 1, 2009·Stress : the International Journal on the Biology of Stress·Angela J Grippo, Alan Kim Johnson
Feb 11, 2009·Gynäkologisch-geburtshilfliche Rundschau·Matthias Schwab
Jun 2, 2009·Revista española de cardiología·Patricio López-Jaramillo
Oct 15, 2009·Frontiers in Behavioral Neuroscience·Elizabeth C Cottrell, Jonathan R Seckl
Feb 11, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chiara BraconiTushar Patel
Mar 25, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jill KoshiolMaria Teresa Landi
Apr 27, 2010·Nature Genetics·Jason Z LiuJonathan Marchini
May 12, 2010·Addiction Biology·Aryeh I Herman, Mehmet Sofuoglu
May 18, 2010·Mutation Research·Igor KoturbashOlga Kovalchuk
Aug 3, 2010·Biological Psychiatry·Tamara B FranklinIsabelle M Mansuy
Aug 21, 2010·Plant Signaling & Behavior·Alex Boyko, Igor Kovalchuk

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Citations

Aug 25, 2015·Frontiers in Cellular Neuroscience·Mingju CaoMartin G Frasch
May 8, 2015·Journal of Physiological Anthropology·Alan C Logan
Jun 10, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katharina GappIsabelle M Mansuy
Nov 10, 2016·International Journal of Environmental Research and Public Health·Susan L Prescott, Alan C Logan
Nov 25, 2016·Scientific Reports·J Keiko McCrearyGerlinde A S Metz
Jul 14, 2018·Scientific Reports·Jamshid FarajiGerlinde A S Metz
Mar 17, 2020·Frontiers in Immunology·Valeria Garcia-FloresNardhy Gomez-Lopez
Apr 14, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Veronica A PearBarbara Abrams
May 9, 2019·Environmental Epigenetics·J Keiko McCrearyGerlinde A S Metz
Nov 11, 2019·Neuroscience and Biobehavioral Reviews·Paula DesplatsMartin G Frasch

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