Ancestral state reconstruction by comparative analysis of a GRN kernel operating in echinoderms

Development Genes and Evolution
Eric M ErkenbrackLaura Romano

Abstract

Diverse sampling of organisms across the five major classes in the phylum Echinodermata is beginning to reveal much about the structure and function of gene regulatory networks (GRNs) in development and evolution. Sea urchins are the most studied clade within this phylum, and recent work suggests there has been dramatic rewiring at the top of the skeletogenic GRN along the lineage leading to extant members of the euechinoid sea urchins. Such rewiring likely accounts for some of the observed developmental differences between the two major subclasses of sea urchins-cidaroids and euechinoids. To address effects of topmost rewiring on downstream GRN events, we cloned four downstream regulatory genes within the skeletogenic GRN and surveyed their spatiotemporal expression patterns in the cidaroid Eucidaris tribuloides. We performed phylogenetic analyses with homologs from other non-vertebrate deuterostomes and characterized their spatiotemporal expression by quantitative polymerase chain reaction (qPCR) and whole-mount in situ hybridization (WMISH). Our data suggest the erg-hex-tgif subcircuit, a putative GRN kernel, exhibits a mesoderm-specific expression pattern early in Eucidaris development that is directly downstream of the ini...Continue Reading

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Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eric M Erkenbrack, Eric H Davidson

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Citations

Jul 9, 2016·Current Opinion in Genetics & Development·Maria Ina ArnoneRossella Annunziata
Nov 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eric M Erkenbrack
Sep 29, 2018·Genesis : the Journal of Genetics and Development·Tanvi ShashikantCharles A Ettensohn
Jun 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Miri MorgulisSmadar Ben-Tabou de-Leon
May 10, 2019·Communications Biology·Eric M Erkenbrack, Jeffrey R Thompson
Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey R ThompsonDavid J Bottjer
May 26, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Eric M Erkenbrack, Elizabeth Petsios
Oct 17, 2017·History and Philosophy of the Life Sciences·Douglas H Erwin
Jan 12, 2020·Communications Biology·Eric M Erkenbrack, Jeffrey R Thompson
Feb 12, 2017·Developmental Biology·Gregory A Cary, Veronica F Hinman

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