Abstract
Like cells, all mammals have a limited life span. Among cells there are a few exceptions (e.g., immortal cells), among mammals not, even if some of them live longer. Many in vitro and in vivo studies support the consensus that telomere length is strongly correlated with life span. At the somatic cellular level, long telomeres have been associated with longer life span. A different situation can be seen in immortal cells, such as cancer, germ and stem cells, where telomeres are maintained by telomerase, a specialized reverse transcriptase that is involved in synthesis of telomeres. Irrespective of telomere length, if telomerase is active, telomeres can be maintained at a sufficient length to ensure cell survival. To the contrary, telomeres shorten progressively with each cell division and when a critical telomere length (Hayflick limit) is reached, the cells undergo senescence and subsequently apoptosis. In mammals, those with the longest telomeres (e.g., mice) have the shortest life span. Furthermore, the shorter the mean telomere length, the longer the mean life span, as observed in humans (10-14 kpb) and bowhead-whales (undetermined telomere length), which have the longest mean life span among mammals. Over the past centuries...Continue Reading
References
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C AllsoppC B Harley
Sep 27, 1990·Nature·D Kipling, H J Cooke
Feb 1, 1990·Molecular and Cellular Biology·T de LangeH E Varmus
Jan 1, 1996·Annual Review of Biochemistry·C W Greider
Oct 23, 1997·Cell·M A BlascoC W Greider
Mar 30, 1999·Experimental Cell Research·C MondelloF Nuzzo
Aug 4, 1999·The Journal of Experimental Medicine·N RuferP M Lansdorp
Sep 24, 1999·Biochemical and Biophysical Research Communications·S KakuoT Ide
Apr 1, 2000·The Journal of Biological Chemistry·M M OuelletteW E Wright
Nov 10, 2000·Nucleic Acids Research·M T Hemann, C W Greider
Aug 25, 2001·EMBO Reports·E SamperM A Blasco
Feb 14, 2002·Critical Reviews in Oncology/hematology·Meaghan P GrangerJerry W Shay
Feb 8, 2003·Lancet·Richard M CawthonRichard A Kerber
Feb 22, 2003·Nucleic Acids Research·H CherifC N Hales
Jul 12, 2003·Experimental Gerontology·Carol M VleckDavid Vleck
Feb 14, 2004·The Journal of Biological Chemistry·Carmen Martin-RuizThomas von Zglinicki
Citations
Mar 25, 2014·Histochemistry and Cell Biology·Liu HeJian Song
Mar 14, 2007·British Journal of Cancer·E Hiyama, K Hiyama
Nov 9, 2010·Cell Transplantation·Antonella PoloniPietro Leoni