Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets

Legal Medicine
Kornkiat VongpaisarnsinJoel Gelernter

Abstract

The main purpose of this work was to identify a set of AIMs that stratify the genetic structure and diversity of the Thai population from a high-throughput autosomal genome-wide association study. In this study, more than one million SNPs from the international HapMap database and the Thai depression genome-wide association study have been examined to identify ancestry informative markers (AIMs) that distinguish between Thai populations. An efficient strategy is proposed to identify and characterize such SNPs and to test high-resolution SNP data from international HapMap populations. The best AIMs are identified to stratify the population and to infer genetic ancestry structure. A total of 124 AIMs were clearly clustered geographically across the continent, whereas only 89 AIMs stratified the Thai population from East Asian populations. Finally, a set of 273 AIMs was able to distinguish northern from southern Thai subpopulations. These markers will be of particular value in identifying the ethnic origins in regions where matching by self-reports is unavailable or unreliable, which usually occurs in real forensic cases.

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Citations

Apr 10, 2016·International Journal of Legal Medicine·Kornkiat VongpaisarnsinPiyawan Dangkao
Sep 6, 2018·Genome Biology and Evolution·Ranajit Das, Priyanka Upadhyai
Aug 8, 2019·International Journal of Legal Medicine·Ju Yeon JungDennis McNevin
Apr 6, 2020·International Journal of Legal Medicine·Tikumphorn SathirapatyaKornkiat Vongpaisarnsin

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