Anchors and signals: the diverse roles of integrins in development

Current Topics in Developmental Biology
Aidan P Maartens, Nicholas H Brown

Abstract

Integrins mediate cell adhesion by providing a link between the actin cytoskeleton and the extracellular matrix. As well as acting to anchor cells, integrin adhesions provide sensory input via mechanotransduction and synergism with signaling pathways, and provide the cell with the conditions necessary for differentiation in a permissive manner. In this review, we explore how integrins contribute to development, and what this tells us about how they work. From a signaling perspective, the influence of integrins on cell viability and fate is muted in a developmental context as compared to cell culture. Integrin phenotypes tend to arise from a failure of normally specified cells to create tissues properly, due to defective adhesion. The diversity of integrin functions in development shows how cell adhesion is continuously adjusted, both within and between animals, to fit developmental purpose.

Citations

Jun 16, 2016·Frontiers in Physiology·Sujeenthar Tharmalingam, David R Hampson
Oct 8, 2016·Cell Adhesion & Migration·Yukinori EndoKenneth M Yamada
Dec 22, 2016·Biological Chemistry·Ellen Dickreuter, Nils Cordes
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Jan 28, 2017·Development·Nicolle A Bonar, Christian P Petersen
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