Ancient animal genome architecture reflects cell type identities

Nature Ecology & Evolution
Bob ZimmermannOleg Simakov

Abstract

The level of conservation of ancient metazoan gene order (synteny) is remarkable. Despite this, the functionality of the vast majority of such regions in metazoan genomes remains elusive. Utilizing recently published single-cell expression data from several anciently diverging metazoan species, we reveal the level of correspondence between cell types and genomic synteny, identifying genomic regions conferring ancient cell type identity.

References

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Citations

May 26, 2020·GigaScience·Heiner KuhlChristophe Klopp
Aug 7, 2019·Nature Ecology & Evolution·Maja Adamska
Dec 10, 2019·Annual Review of Animal Biosciences·Caroline B Albertin, Oleg Simakov
Jul 27, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lukáš KratochvílMichail Rovatsos

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Datasets Mentioned

BETA
GSE95723
and
GSE111068

Methods Mentioned

BETA
gene neighbourhood
PCA

Software Mentioned

OrthoFinder
JASPAR
GeneMarkS
FastME

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