Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers.

Science Advances
Maïté RivollatWolfgang Haak

Abstract

Starting from 12,000 years ago in the Middle East, the Neolithic lifestyle spread across Europe via separate continental and Mediterranean routes. Genomes from early European farmers have shown a clear Near Eastern/Anatolian genetic affinity with limited contribution from hunter-gatherers. However, no genomic data are available from modern-day France, where both routes converged, as evidenced by a mosaic cultural pattern. Here, we present genome-wide data from 101 individuals from 12 sites covering today's France and Germany from the Mesolithic (N = 3) to the Neolithic (N = 98) (7000-3000 BCE). Using the genetic substructure observed in European hunter-gatherers, we characterize diverse patterns of admixture in different regions, consistent with both routes of expansion. Early western European farmers show a higher proportion of distinctly western hunter-gatherer ancestry compared to central/southeastern farmers. Our data highlight the complexity of the biological interactions during the Neolithic expansion by revealing major regional variations.

References

Jul 21, 2004·Lancet·Fabio LanfrancoEberhard Nieschlag
Dec 22, 2006·Molecular Biology and Evolution·Heather L NortonMark D Shriver
Dec 30, 2006·PLoS Genetics·Nick PattersonDavid Reich
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·J BurgerM G Thomas
Mar 21, 2009·Alcoholism, Clinical and Experimental Research·Richard ShervaLaura J Bierut
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Jun 3, 2010·Cold Spring Harbor Protocols·Matthias Meyer, Martin Kircher
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Aug 19, 2010·American Journal of Physical Anthropology·Marie-France DeguillouxLuc Laporte
Nov 26, 2010·PloS One·Tomislav MaricicSvante Pääbo
Aug 6, 2011·Molecular Biology and Evolution·Chad D HuffStephen L Guthery
Oct 25, 2011·Nucleic Acids Research·Martin KircherMatthias Meyer
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·R Alexander BentleyAlasdair Whittle
Sep 11, 2012·Genetics·Nick PattersonDavid Reich
Mar 26, 2013·Current Biology : CB·Qiaomei FuJohannes Krause
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jesse DabneyMatthias Meyer
Oct 12, 2013·Science·Ruth BollonginoJoachim Burger
Nov 22, 2013·Nature·Maanasa RaghavanEske Willerslev
Oct 22, 2014·Nature Communications·Cristina GambaRon Pinhasi
Nov 26, 2014·BMC Bioinformatics·Thorfinn KorneliussenRasmus Nielsen
Dec 10, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nadin RohlandDavid Reich
Jun 13, 2015·Nature·Morten E AllentoftEske Willerslev
Nov 17, 2015·Nature Communications·Eppie R JonesDaniel G Bradley
Nov 26, 2015·Nature·Iain MathiesonDavid Reich
Feb 13, 2016·BMC Research Notes·Mikkel SchubertLudovic Orlando
Apr 3, 2016·Genome Biology·Alexander PeltzerKay Nieselt
Apr 17, 2016·Nucleic Acids Research·Hansi WeissensteinerSebastian Schönherr
Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Zuzana HofmanováJoachim Burger
Oct 23, 2016·American Journal of Physical Anthropology·Maïté RivollatMarie-France Deguilloux
Jan 1, 2015·Journal of World Prehistory·B HorejsA Galik
Jul 28, 2016·Nature·Iosif LazaridisDavid Reich
Dec 29, 2016·European Journal of Human Genetics : EJHG·Maïté RivollatPascale Gerbault
Dec 22, 2017·Journal of Archaeological Method and Theory·Anthony DenaireAlasdair Whittle
Feb 1, 2018·Nature Communications·Alissa MittnikJohannes Krause

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
PCA
deaminations

Software Mentioned

Geneious
Rsamtools
qp3Pop
BWA ( Aligner )
samtools
AdapterRemoval
HaploGrep
EIGENSOFT
DATES
shrinkmode

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.