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Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region

Proceedings of the National Academy of Sciences of the United States of America

Oct 31, 2006

Dagan A LoiselSusan C. Alberts

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Abstract

Precise regulation of MHC gene expression is critical to vertebrate immune surveillance and response. Polymorphisms in the 5' proximal promoter region of the human class II gene HLA-DQA1 have been shown to influence its transcriptional regulation and may contribute to the pathogenesis o...read more

Mentioned in this Paper

HLA-DQ Antigens
Nonhuman primate
Transcriptional Regulation
Papio
Functional Differentiation
Vertebrates
Genetic Polymorphism
Early Promoters, Genetic
Papio cynocephalus
Genes, MHC Class II
Paper Details
References
    • References61
    • Citations32
    • References61
    • Citations32
  • Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region

    Proceedings of the National Academy of Sciences of the United States of America

    Oct 31, 2006

    Dagan A LoiselSusan C. Alberts

    PMID: 17053068

    DOI: 10.1073/pnas.0607662103

    Abstract

    Precise regulation of MHC gene expression is critical to vertebrate immune surveillance and response. Polymorphisms in the 5' proximal promoter region of the human class II gene HLA-DQA1 have been shown to influence its transcriptional regulation and may contribute to the pathogenesis o...read more

    Mentioned in this Paper

    HLA-DQ Antigens
    Nonhuman primate
    Transcriptional Regulation
    Papio
    Functional Differentiation

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    Paper Details
    References
    • References61
    • Citations32
    • References61
    • Citations32
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