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Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region

Proceedings of the National Academy of Sciences of the United States of America

Oct 21, 2006

Dagan A LoiselSusan C Alberts

Abstract

Precise regulation of MHC gene expression is critical to vertebrate immune surveillance and response. Polymorphisms in the 5' proximal promoter region of the human class II gene HLA-DQA1 have been shown to influence its transcriptional regulation and may contribute to the pathogenesis o...read more

Mentioned in this Paper

Vertebrates
Pathogenic Aspects
Transcriptional Regulation
Pathogenesis
Nonhuman primate
Transcription, Genetic
Papio
Promoter
Genes, MHC Class II
HLA-DQA1
Paper Details
References
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  • Citations37
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Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region

Proceedings of the National Academy of Sciences of the United States of America

Oct 21, 2006

Dagan A LoiselSusan C Alberts

PMID: 17053068

DOI: 10.1073/pnas.0607662103

Abstract

Precise regulation of MHC gene expression is critical to vertebrate immune surveillance and response. Polymorphisms in the 5' proximal promoter region of the human class II gene HLA-DQA1 have been shown to influence its transcriptional regulation and may contribute to the pathogenesis o...read more

Mentioned in this Paper

Vertebrates
Pathogenic Aspects
Transcriptional Regulation
Pathogenesis
Nonhuman primate
Transcription, Genetic
Papio
Promoter
Genes, MHC Class II
HLA-DQA1

Similar Papers Found In These Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Immunologic Surveillance

Immunological surveillance occurs when T-cells detect and destroy virally infected or neoplastically transformed cells in the body. Discover the latest research on immunologic surveillance here.

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Paper Details
References
  • References61
  • Citations37
12345...
  • References61
  • Citations37
1234
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