Aug 10, 2015

Ancient trans-acting siRNAs modulate auxin sensitivity in the moss Physcomitrella patens

BioRxiv : the Preprint Server for Biology
Yevgeniy PlavskinMarja CP Timmermans

Abstract

Novel developmental programs often evolve via the cooption of existing genetic networks. To gain insight into this evolutionary process, we explored an independent cooption event of the TAS3 tasiRNA pathway, which has been repeatedly redeployed over the course of plant evolution, in the moss Physcomitrella patens . We find an ancestral role for this pathway in the spatial regulation of a conserved set of Auxin Response Factors. In moss, this results in stochastic patterning of the filamentous protonemal tissue. Through a combination of computational modeling and experimentation, we demonstrate that tasiRNA regulation confers sensitivity and robustness onto the auxin response. The loss of auxin sensitivity is paralleled by decreased developmental sensitivity to nitrogen, a key environmental signal. We propose that the properties lent to the auxin response gene regulatory network by tasiRNAs, along with their ability to stochastically modulate development in response to environmental cues, have contributed to the tasiRNA-ARF module’s repeated cooption over the course of plant evolution.

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Mentioned in this Paper

Spatial Memory
Biochemical Pathway
RNA, Small Interfering
Regulation of Biological Process
Auxins
Environment
Physcomitrella patens
Trans-Acting siRNA
Nitrogen
Gene Regulatory Networks

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