Ancient Transcription Factors in the News

MBio
Irina Artsimovitch, Stefan H Knauer

Abstract

In every cell from bacteria to mammals, NusG-like proteins bind transcribing RNA polymerase to modulate the rate of nascent RNA synthesis and to coordinate it with numerous cotranscriptional processes that ultimately determine the transcript fate. Housekeeping NusG factors regulate expression of the bulk of the genome, whereas their highly specialized paralogs control just a few targets. In Escherichiacoli, NusG stimulates silencing of horizontally acquired genes, while its paralog RfaH counters NusG action by activating a subset of these genes. Acting alone or as part of regulatory complexes, NusG factors can promote uninterrupted RNA synthesis, bring about transcription pausing or premature termination, modulate RNA processing, and facilitate translation. Recent structural and mechanistic studies of NusG homologs from all domains of life reveal molecular details of multifaceted interactions that underpin their unexpectedly diverse regulatory roles. NusG proteins share conserved binding sites on RNA polymerase and many effects on the transcription elongation complex but differ in their mechanisms of recruitment, interactions with nucleic acids and secondary partners, and regulatory outcomes. Strikingly, some can alternate betw...Continue Reading

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Citations

Oct 3, 2020·Critical Reviews in Biochemistry and Molecular Biology·Alexander V YakhninPaul Babitzke
Apr 22, 2020·Scientific Reports·Benjamin R DudenhoefferStefan H Knauer
Aug 17, 2020·International Journal of Molecular Sciences·Adrian Jun ChuXiao Yang
Dec 18, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Simona KrasnopolskyRan Taube
Oct 29, 2020·MBio·Bing WangIrina Artsimovitch
Jan 26, 2021·Frontiers in Microbiology·Bing Wang, Irina Artsimovitch
Apr 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Surajit ChatterjeeNils G Walter
Jun 14, 2021·Journal of Molecular Biology·Amr ElghondaklyWade C Winkler
Aug 12, 2021·Scientific Reports·Swati Gupta, Debnath Pal
Aug 5, 2021·Annual Review of Microbiology·Robert Landick

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Methods Mentioned

BETA
nuclear magnetic resonance
X-ray
NMR

Software Mentioned

NusG SP

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