Ancillary studies in cytology: Secondary or necessary?

Cancer Cytopathology
Douglas P Clark

Abstract

Ancillary studies are rapidly becoming an integral and necessary aspect of cytologic analysis. In addition to morphologic features, cytologic specimens contain an enormous amount of information content within their molecules that should be tapped to add value to these samples. Fortunately, a large number of existing and emerging technologies exist to provide access to this information. Adoption of these technologies will require continued attention to fundamental aspects of specimen procurement, handling, and processing to ensure testing accuracy. Successful implementation of ancillary studies will depend on rigorous validation of assays and the development of evidence-based guidelines for their use in patients. Cytopathologists must embrace the role of ancillary test stewardship to ensure the future clinical use of cytologic specimens.

References

Oct 3, 2006·Nature Biotechnology·Walter SchubertAndreas W M Dress
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thaer KhourySwati Kulkarni
Mar 25, 2011·Cancer Cytopathology·Helen M MooreJim Vaught
Jul 20, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Michael J GerdesFiona Ginty
Jul 16, 2013·Nature Methods·Rongqin KeMats Nilsson
Oct 3, 2013·Scientific Reports·David TamboreroNuria Lopez-Bigas
Dec 18, 2013·The New England Journal of Medicine·Mark Schiffman, Diane Solomon
Mar 1, 2014·Science·Je Hyuk LeeGeorge M Church
Mar 4, 2014·Nature Medicine·Michael AngeloGarry P Nolan
Mar 4, 2014·Nature Methods·Charlotte GiesenBernd Bodenmiller
Apr 1, 2014·Nature Methods·Eric LubeckLong Cai
Jul 16, 2014·Seminars in Oncology·Barbara A Conley, James H Doroshow
Jun 20, 2016·Acta Cytologica·Güliz A BarkanDorothy L Rosenthal
Feb 12, 2017·Cell·Nicholas McGranahan, Charles Swanton
Apr 20, 2017·Genome Medicine·Zachary R ChalmersGarrett M Frampton
Jul 21, 2017·Cancer Cytopathology·David H HwangLynette M Sholl
Aug 19, 2017·Science·Mathias UhlenFredrik Ponten
Dec 19, 2017·Archives of Pathology & Laboratory Medicine·James S LewisWilliam C Faquin
Feb 22, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sinchita Roy-ChowdhuriRajyalakshmi Luthra

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Citations

May 24, 2019·Archives of Pathology & Laboratory Medicine·He Wang, Nirag Jhala

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