PMID: 37784May 1, 1979

Andrenogonadal interactions in nicotine-induced alteration of steroidogenesis in male rat

Andrologia
N M BiswasC Deb

Abstract

Chronic nicotine administration in larger doses inhibits steroidogenesis in testis. This inhibition is possibly secondary to increased adrenomedullary norepinephrine activity, since the anti-steroidogenic effect of nicotine can be prevented by alpha-adrenergic blocker like phentolamine. In vitro incubation of testicular slices with nicotine failed to elicit any appreciable effect on delta 5-3 beta-hydroxysteroid dehydrogenase activity indicating lack of direct action of nicotine on testicular steroidogenesis.

References

Jan 1, 1989·Archives of Andrology·A M AttiaM M Mossa
Jul 1, 1992·Andrologia·I GerhardB Runnebaum
Oct 5, 2019·Tobacco Induced Diseases·Mahmoud Y HaikAla-Eddin Al Moustafa

Citations

May 1, 1967·Acta Endocrinologica·J LevinE H Friedrich
Jan 1, 1955·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·N A HILLARP, B HOKFELT
Sep 1, 1960·Annals of the New York Academy of Sciences·D T WATTS
Jun 1, 1962·Journal of Reproduction and Fertility·B A CROSS, I A SILVER
May 1, 1955·British Medical Bulletin·B A CROSS
Apr 1, 1952·The Journal of Pathology and Bacteriology·A G OETTLE, R G HARRISON

Related Concepts

Z-Max
Structure of Interstitial Cell of Leydig
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists
Testis
3-Hydroxysteroid Dehydrogenases
Catecholamines
Cytochemistry
Fanconi Like Syndrome
Adrenal Medulla

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