Androgen Action in the Ovary

Frontiers in Endocrinology
Stephen Franks, Kate Hardy

Abstract

Androgen production by the ovary is an essential requirement for normal cyclical secretion of estradiol but its physiological role extends to important actions on both preantral and antral follicle development, including promotion of granulosa cell proliferation. It is likely only in mature antral follicles that androgens encourage apoptosis and consequent follicle atresia, and this may be an important mechanism to ensure mono-follicular ovulation in primates, including humans. Recent studies have provided new insight into the mechanism of androgen signaling in the ovary which involves both genomic and non-genomic effects that are complementary in effecting a cellular response. In polycystic ovary syndrome, a condition characterized by intra-ovarian androgen excess, aberrant development of both preantral and antral follicles is a salient feature. We present evidence that local action of androgens plays a part in such abnormalities. Finally, we review the role of androgens in follicle atresia and conclude that the effects are part of the normal physiology of follicle maturation.

References

Oct 1, 1989·The Journal of Clinical Endocrinology and Metabolism·G F EricksonD A Magoffin
Sep 1, 1987·The Journal of Clinical Endocrinology and Metabolism·A DunaifA Dobrjansky
Jun 1, 1995·The Journal of Endocrinology·M TetsukaS G Hillier
Sep 28, 1995·The New England Journal of Medicine·S Franks
Apr 1, 1994·Molecular and Cellular Endocrinology·S G HillierC D Smyth
Jan 1, 1997·Human Reproduction·S G HillierH M Fraser
Jun 24, 1998·The Journal of Clinical Investigation·K A VendolaC A Bondy
Jul 14, 1998·The Journal of Clinical Endocrinology and Metabolism·S J WeilC A Bondy
Aug 26, 1998·Journal of Reproduction and Fertility·A A MurrayN Spears
Jul 6, 2002·The Journal of Endocrinology·D H AbbottS Franks
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Gustavo A R MacielGregory F Erickson
Mar 25, 2005·The New England Journal of Medicine·David A Ehrmann
Dec 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hiroko ShiinaShigeaki Kato
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelKenneth P McNatty
Feb 7, 2007·The Journal of Endocrinology·Rachel A ForsdikeStephen Franks
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa J WebberStephen Franks
May 15, 2007·Endocrinology·Louise ManneråsElisabet Stener-Victorin
Aug 19, 2007·The Journal of Clinical Endocrinology and Metabolism·Sharron A StubbsKate Hardy
May 6, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·A I QureshiH D Mason
May 24, 2008·Human Reproduction Update·Stephen FranksKate Hardy
Mar 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Paul A FowlerPeter J O'Shaughnessy
Jun 15, 2011·Molecular and Cellular Endocrinology·Emily B AskewElizabeth M Wilson
Feb 16, 2012·Endocrinology·E Leonie A F van HoutenJenny A Visser
Jun 5, 2012·The Journal of Clinical Endocrinology and Metabolism·Janni Vikkelsø JeppesenClaus Yding Andersen
Jun 12, 2012·The Journal of Clinical Investigation·Aritro SenStephen R Hammes
Oct 23, 2012·Molecular and Cellular Endocrinology·Vasantha Padmanabhan, Almudena Veiga-Lopez

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Citations

Aug 7, 2019·Journal of the Endocrine Society·Selma Feldman WitchelAlexia S Peña
Oct 12, 2018·Journal of Molecular Histology·Rebeca Chávez-Genaro, Gabriel Anesetti
Oct 6, 2020·Frontiers in Endocrinology·Kristine LøsslClaus Yding Andersen
Jul 28, 2020·Journal of Assisted Reproduction and Genetics·Bruce I Rose, Samuel E Brown
Mar 12, 2019·Current Opinion in Obstetrics & Gynecology·Pedro Montoya-BoteroNikolaos P Polyzos
Jan 19, 2021·Advanced Biomedical Research·Faeze Fazel TorshiziReza Majidzadeh Heravi
Jan 23, 2021·International Journal of Molecular Sciences·Antonietta SantoroRosaria Meccariello
Jan 16, 2021·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Yasmine AbdelmeguidMostafa Kotb
Feb 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Asieh MansourMostafa Qorbani
May 1, 2021·International Journal of Molecular Sciences·Karolina WołodkoAntónio Galvão
Apr 30, 2020·Saudi Journal of Biological Sciences·Salina Y Saddick
Dec 17, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Heidi Vanden BrinkMarla E Lujan

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis