Androgen activity as a risk factor for impaired glucose tolerance in postmenopausal women

Diabetes Care
H Larsson, B Ahrén

Abstract

Low sex hormone-binding globulin (SHBG) has been proposed as a risk factor for NIDDM development in women. Our aim was to study the relationship between SHBG and androgen activity and glucose tolerance, as well as insulin sensitivity, in women with impaired glucose tolerance (IGT). We studied 22 women with IGT and 46 women with normal glucose tolerance (NGT) aged 57-59 years. Free testosterone (androgen activity) was determined as the testosterone-to-SHBG ratio. A World Health Organization 75-g oral glucose tolerance test (OGTT) was performed, and insulin sensitivity was measured with a euglycemic-hyperinsulinemic clamp. Fasting glucose (P = 0.021), 2-h blood glucose after the OGTT (P < 0.001), and fasting insulin (P = 0.009) were higher in the IGT group, while insulin sensitivity did not differ significantly between the two groups (P = 0.065). We found that SHBG levels were lower in the IGT group (P = 0.004), while the testosterone-to-SHBG ratio was higher in the IGT than in the NGT group (P = 0.004). Insulin sensitivity correlated negatively with testosterone-to-SHBG ratio in both groups. The correlation was higher in the IGT (r = -0.67, P = 0.001) than in the NGT group (r = -0.29, P = 0.047). In contrast, the 2-h blood gluco...Continue Reading

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