Jan 29, 2008

Androgen cell signaling pathways involved in neuroprotective actions

Hormones and Behavior
Christian J PikeEmily R Rosario

Abstract

As a normal consequence of aging in men, testosterone levels significantly decline in both serum and brain. Age-related testosterone depletion results in increased risk of dysfunction and disease in androgen-responsive tissues, including brain. Recent evidence indicates that one deleterious effect of age-related testosterone loss in men is increased risk for Alzheimer's disease (AD). We discuss recent findings from our laboratory and others that identify androgen actions implicated in protecting the brain against neurodegenerative diseases and begin to define androgen cell signaling pathways that underlie these protective effects. Specifically, we focus on the roles of androgens as (1) endogenous negative regulators of beta-amyloid accumulation, a key event in AD pathogenesis, and (2) neuroprotective factors that utilize rapid non-genomic signaling to inhibit neuronal apoptosis. Continued elucidation of cell signaling pathways that contribute to protective actions of androgens should facilitate the development of targeted therapeutic strategies to combat AD and other age-related neurodegenerative diseases.

Mentioned in this Paper

Pathogenic Aspects
Prostatic Neoplasms
Androgen Receptor
Biochemical Pathway
Cyclic AMP-Responsive DNA-Binding Protein
Testosterone Measurement
Androgen Effect
Exertion
Salicylhydroxamic acid
Hydrogen Peroxide

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