Androgen deficiency: effects on body composition.

Pituitary
Karen K Miller

Abstract

Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects of testosterone administration on muscle in men are well-established, and current understanding of the underlying mechanisms are discussed. Randomized, placebo-controlled studies have been performed to investigate the effects of testosterone administration on body composition in a number of male hypogonadal states, including HIV-associated weight loss, supraphysiologic glucocorticoid administration, aging and obesity, with variable outcomes, and the results are reviewed. There are few data investigating the effects of hypoandrogenemia or androgen replacement on body composition in women, in whom endogenous testosterone levels are a fraction of those in men. A recent randomized, placebo-controlled study of physiologic testosterone replacement therapy in women with profound hypoandrogenemia due to hypopituitarism demonstrated an increase in skeletal muscle mass but no change in body fat. Further research is needed to...Continue Reading

References

Dec 15, 1976·American Journal of Obstetrics and Gynecology·M H KimC Dupon
May 1, 1988·Endocrine Reviews·J D Wilson
Mar 15, 1974·American Journal of Obstetrics and Gynecology·H L JuddS S Yen
Feb 1, 1993·Journal of the American Geriatrics Society·J E MorleyH M Perry
Jun 10, 1996·Archives of Internal Medicine·I R ReidJ P Stapleton
Jun 1, 1997·The Journal of Clinical Endocrinology and Metabolism·R SihC Ross
Sep 26, 1997·AIDS·G O Coodley, M K Coodley
Feb 11, 1998·AJR. American Journal of Roentgenology·L KatznelsonA Klibanski
Sep 30, 1999·The New England Journal of Medicine·W ArltB Allolio
Feb 22, 2000·JAMA : the Journal of the American Medical Association·S BhasinG Beall
Sep 7, 2000·The New England Journal of Medicine·J L ShifrenN A Mazer
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·S M HarmanUNKNOWN Baltimore Longitudinal Study of Aging
Feb 15, 2001·The Journal of Urology·E R FreemanE J McGuire
Apr 26, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A M KennyL G Raisz
Sep 22, 2001·The American Journal of Medicine·E A WhitselD S Siscovick
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Atam B SinghShalender Bhasin
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Henry A FeldmanJohn B McKinlay
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Indrani Sinha-HikimShalender Bhasin
Nov 13, 2002·JAMA : the Journal of the American Medical Association·Marc R BlackmanS Mitchell Harman
Dec 5, 2002·The Medical Journal of Australia·Andrea J CussonsJohn P Walsh
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·C SteidleUNKNOWN North American AA2500 T Gel Study Group
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Bronwyn A L CrawfordDavid J Handelsman
Jul 17, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gary A WittertJohn E Morley
Dec 20, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shalender BhasinNestor F Gonzalez-Cadavid
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Karen K MillerAnne Klibanski
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Linda J WoodhouseShalender Bhasin
Nov 13, 2004·The Journal of Clinical Endocrinology and Metabolism·David E LaaksonenJukka T Salonen
Nov 25, 2004·The Journal of Clinical Endocrinology and Metabolism·Shalender BhasinThomas W Storer
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·H H ChoiS Bhasin
May 3, 2005·Obstetrics and Gynecology·John E BusterPeter Casson
Jul 15, 2005·The Journal of Clinical Endocrinology and Metabolism·James SimonSusan Davis
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Olga M CalofShalender Bhasin

❮ Previous
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Citations

May 28, 2013·Journal of the International Society of Sports Nutrition·Shawn M TalbottMike Pugh
Jul 24, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ozkan GungorErcan Ok
Nov 4, 2010·Breast Cancer Research and Treatment·G J van LondenS L Greenspan
Aug 12, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Abdulmaged M Traish
May 11, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·E Lichar DillonMelinda Sheffield-Moore
Jun 1, 2013·Clinical Obesity·R Smith, N Finer
Jan 14, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G-X TianZ-N Mo
Oct 4, 2015·Endocrine-related Cancer·Casey de RooyAda S Cheung
Aug 2, 2018·Nature Reviews. Endocrinology·John A Batsis, Dennis T Villareal
Jan 16, 2009·Journal of the American Society of Nephrology : JASN·Juan Jesús CarreroPeter Stenvinkel
Feb 9, 2021·Therapeutic Advances in Endocrinology and Metabolism·Ingrid BrethertonAda S Cheung
Oct 31, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bradley S GordonRobert A Casero
Apr 27, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
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