Androgen deprivation therapy for prostate cancer: current status and future prospects

The Prostate
Hiroshi MiyamotoChawnshang Chang

Abstract

Androgens play a major role in promoting the development and progression of prostate cancer. As a result, androgen ablation or blockade of androgen action through the androgen receptor (AR) has been the cornerstone of treatment of advanced prostate cancer. Different strategies involving this hormonal therapy produce a significant clinical response in most of the patients, but most responders eventually lose dependency, resulting in mortality. Thus, whether hormonal therapy contributes to the improvement of overall survival rates, especially in patients with advanced prostate cancer, remains controversial. However, patients with advanced disease clearly have a benefit from androgen deprivation-based treatment for palliating their symptoms and for improving the quality of their lives. In order to improve overall survival, novel treatment strategies that prolong the androgen-dependent state and that are useful for androgen-independent disease based on specific molecular mechanisms need to be identified.

References

Mar 9, 1991·BMJ : British Medical Journal·D J ChadwickJ C Gingell
Jan 1, 1990·The Prostate·P Martikainen, J Isaacs
Jun 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A EisenbergerM A Friedman
Dec 1, 1986·Cancer·L H KlotzW F Whitmore
Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
Apr 1, 1988·British Journal of Urology·F LabrieN Bergeron
Jan 1, 1988·American Journal of Clinical Oncology·J SandowK Engelbart
Sep 15, 1988·Biochemical and Biophysical Research Communications·C Chang, J Kokontis
Oct 1, 1967·The Journal of Urology
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
Jan 1, 1984·The Prostate·J T Isaacs
Jan 1, 1996·The Journal of Urology·D K Wysowski, J L Fourcroy
Mar 31, 1995·The Journal of Biological Chemistry·G JensterA O Brinkmann
May 25, 1995·The New England Journal of Medicine·M E TaplinS P Balk
Jan 1, 1994·Annual Review of Biochemistry·D W Russell, J D Wilson
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Nov 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D McKillopR A Yates
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BoccardoM Battaglia
Dec 15, 1995·The Journal of Biological Chemistry·E LangleyE M Wilson
Jul 3, 1996·Journal of the National Cancer Institute·C N RobertsonR L Fine
Aug 16, 1996·The Journal of Biological Chemistry·L V Nazareth, N L Weigel

❮ Previous
Next ❯

Citations

Oct 3, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Guozheng LiuDonald J Hnatowich
Oct 9, 2007·Cancer Chemotherapy and Pharmacology·Paul R HutsonGeorge Wilding
Sep 11, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaofeng XuJianping Gao
Sep 19, 2012·The Journal of Organic Chemistry·Shigehiro TohyamaTomio Morino
Nov 9, 2005·Prostate Cancer and Prostatic Diseases·U FerreiraN R Netto
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Harsh Vardhan JainAvner Friedman
Jan 21, 2010·The Journal of Biological Chemistry·X Edward ZhouH Eric Xu
Jul 17, 2012·The Journal of Biological Chemistry·Chin-Hee SongKeesook Lee
Aug 19, 2008·The Journal of Biological Chemistry·Harryl D MartinezMichael E Wright
Apr 12, 2013·Carcinogenesis·Alissa R VeroneHannelore V Heemers
May 18, 2012·Japanese Journal of Clinical Oncology·Yi LiHiroshi Miyamoto
Apr 5, 2007·Journal of the National Cancer Institute·Hiroshi MiyamotoChawnshang Chang
Nov 30, 2011·Anti-cancer Drugs·Roberto IacovelliEnrico Cortesi
Dec 26, 2006·Molecular and Cellular Biology·Tove I KlokkFahri Saatcioglu
Feb 16, 2006·Molecular and Cellular Biology·Yuting LinJialing Xiang
Aug 12, 2010·American Journal of Physiology. Endocrinology and Metabolism·Alejandro GodoyGary J Smith
Feb 18, 2011·Cancer Research·Hannelore V HeemersDonald J Tindall
Jun 2, 2012·Therapeutic Advances in Urology·Amelia AltavillaEnrico Cortesi
Jan 24, 2009·Molecular Endocrinology·Hannelore V HeemersDonald J Tindall
Mar 30, 2012·Molecular Endocrinology·Lucy J SchmidtHannelore V Heemers
Jun 16, 2012·Molecular Endocrinology·Yangsik JeongDavid J Mangelsdorf
Dec 24, 2010·PLoS Medicine·Yangsik JeongDavid J Mangelsdorf
Nov 14, 2013·PloS One·Sazzad HassanGeorge Kulik
Jun 3, 2014·PloS One·Rafaela Rosa-RibeiroHernandes F Carvalho
May 28, 2013·Journal of Molecular Endocrinology·Ye ZhouJeremy O Jones
May 1, 2009·Immunotherapy·Patrick BühlerUrsula Elsässer-Beile
Jun 22, 2014·Japanese Journal of Clinical Oncology·Masaki ShiotaSeiji Naito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.