Androgen deprivation therapy for prostate cancer

Expert Opinion on Pharmacotherapy
Eric A SingerEdward M Messing

Abstract

Androgen deprivation continues to play a crucial role in the treatment of advanced and metastatic prostate cancer. In the 65 years since its use was first described, urologists and medical oncologists have developed new and innovative ways to manipulate the hypothalamic-pituitary-gonadal axis with the goal of alleviating symptoms and prolonging the life of men with prostate cancer. Despite the successes that androgen deprivation therapy has brought, each method and regimen possesses unique benefits and burdens, of which the clinician and patient must be cognizant. This review discusses the first-line androgen deprivation methods and regimens presently in use with special attention paid to their side effects and the management of them, as well as the question of when to initiate androgen deprivation therapy.

References

Dec 1, 1977·Southern Medical Journal·W P JordanD P Byar
Apr 22, 1992·JAMA : the Journal of the American Medical Association·J E JohanssonU B Krusemo
Dec 1, 1986·Cancer·L H KlotzW F Whitmore
Apr 1, 1988·British Journal of Urology·F LabrieN Bergeron
Jan 1, 1988·American Journal of Clinical Oncology·J SandowK Engelbart
Dec 1, 1973·British Journal of Urology·R J ShearerJ D Fergusson
Jan 1, 1996·The Journal of Urology·D K Wysowski, J L Fourcroy
Jan 1, 1994·Annual Review of Biochemistry·D W Russell, J D Wilson
Aug 11, 1994·The New England Journal of Medicine·C L LoprinziN E Klatt
Aug 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A ChangD Trump
Jan 1, 1997·The Annals of Pharmacotherapy·E J Dole, M T Holdsworth
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·J LaverdièreF Labrie
May 1, 1997·The Urologic Clinics of North America·W K KellyH I Scher
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L LoprinziE A Perez
Oct 8, 1998·The New England Journal of Medicine·M A EisenbergerB A Lowe
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F BoccardoG Spano
Apr 13, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M OrlandoD R Chacón
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics· Roach M 3RDM Mohuidden
Sep 9, 2000·The New England Journal of Medicine·E OrwollA Lombardi

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Citations

Aug 2, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lee W Jones
Jul 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tong SunMatthew L Freedman
Dec 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tong SunPhilip W Kantoff
Feb 5, 2009·Critical Reviews in Eukaryotic Gene Expression·Sue A Brown, Theresa A Guise
Dec 23, 2011·ISRN Oncology·Anastasios K GoulioumisHelen Papadaki
Jan 15, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Marianne SchmidQuoc-Dien Trinh
Oct 22, 2011·Urologic Oncology·Eric A Singer, Ramaprasad Srinivasan
Jul 30, 2011·The Urologic Clinics of North America·Keith R Solomon, Michael R Freeman
Jan 10, 2017·Expert Opinion on Therapeutic Targets·Taichi MizushimaHiroshi Miyamoto
Jun 28, 2017·Molecular and Cellular Endocrinology·Satoshi InoueHiroshi Miyamoto
Jun 15, 2010·Therapeutic Advances in Medical Oncology·Christopher J Hoimes, W Kevin Kelly
Nov 16, 2017·Expert Opinion on Drug Metabolism & Toxicology·Charles F PolottiSammy Elsamra
Oct 11, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Elisa Martín-MerinoLuis A García Rodríguez
Mar 1, 2017·Cancers·Peng LiHiroshi Miyamoto
Jan 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Spencer AsayJason D Kenealey
Jan 6, 2015·Oncotarget·Koji IzumiHiroji Uemura
May 4, 2018·Molecular Cancer Therapeutics·Hiroki IdeHiroshi Miyamoto
Dec 8, 2016·Current Opinion in Supportive and Palliative Care·Lisa M Wu, Ali Amidi
Nov 13, 2019·European Journal of Pharmacology·Sebastian StudentRafał Bułdak
Nov 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xumin ZhouXiangming Mao
Jul 12, 2017·International Journal of Surgery Case Reports·Yumiko YokomizoHiroji Uemura
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
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