Androgen Deprivation Therapy Is Associated With Prolongation of QTc Interval in Men With Prostate Cancer

Journal of the Endocrine Society
Thiago Gagliano-JucáShehzad Basaria

Abstract

Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with increased cardiovascular mortality and sudden cardiac death, with some events occurring early after initiation of ADT. Testosterone levels are inversely associated with corrected QT (QTc) interval duration; therefore, prolongation of QTc duration could be responsible for some of these events during ADT. To evaluate changes in QTc duration during ADT. A 6-month prospective cohort study that enrolled men with PCa about to undergo ADT (ADT group) and a control group of men who previously underwent prostatectomy for PCa and never received ADT (non-ADT group). At study entry, all participants were eugonadal and had no history of cardiac arrhythmias or complete bundle branch block. Difference in change in QTc duration from baseline on a 12-lead electrocardiogram at 6, 12, and 24 weeks after initiation of ADT compared with electrocardiograms performed at the same intervals in the non-ADT group. PR, QRS, and QT interval durations were also evaluated. Seventy-one participants formed the analytical sample (33 ADT and 38 non-ADT). ADT was associated with prolongation of the QTc by 7.4 ms compared with the non-ADT group [95% confidence interval (CI) 0.08 to 14....Continue Reading

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Citations

Jan 31, 2019·Cardiovascular Research·Mary BarberJoe-Elie Salem
Jul 23, 2018·The Journal of Clinical Endocrinology and Metabolism·Thiago Gagliano-JucáShehzad Basaria
Oct 17, 2018·American Journal of Physiology. Endocrinology and Metabolism·Thiago Gagliano-JucáShehzad Basaria
Mar 11, 2020·Cardiovascular Toxicology·Andrei Cristian Dan GheorgheGabriela Silvia Gheorghe
Jun 2, 2020·Frontiers in Pharmacology·Pietro Enea LazzeriniPier Leopoldo Capecchi
Jun 6, 2020·Heart Failure Reviews·Vittore CeredaGaetano Lanzetta
May 28, 2019·Nature Reviews. Cardiology·Thiago Gagliano-Jucá, Shehzad Basaria
Feb 6, 2021·International Journal of Molecular Sciences·Virginie GrouthierJoe-Elie Salem
Feb 19, 2021·Journal of the American Heart Association·Kanae HasegawaHiroshi Tada
Jun 23, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zelal Jaber KharabaYassen Alfoteih
Apr 10, 2021·Drugs -- Real World Outcomes·Marco RossiPier Leopoldo Capecchi
Jun 15, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Sakthivel MuniyanRakesh C Kukreja
Jun 10, 2021·Current Problems in Cardiology·Gilmar GutierrezAdrian Baranchuk

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