PMID: 3770993Nov 15, 1986Paper

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: a multivariate analysis approach

International Journal of Cancer. Journal International Du Cancer
M M BrentaniM M Pacheco

Abstract

Androgens have been frequently used in the treatment of breast cancer. However, objective responses seem to vary according to the steroid hormone receptor expression of the tumor. We have studied the relationship between concentrations of androgen receptors (AR) and those of estrogen (ER) and progesterone (PR) receptors by multiple regression and stratified analysis techniques in 154 cases of primary breast carcinomas and 39 cases of benign tumors. Both the proportion of AR-positive tumors and the concentration of AR were dependent upon the coexpression of ER and PR by the specimens. This association was evident for malignant tumors with predominance of the positive correlation between AR and ER over that of AR and PR in post-menopausal patients. In premenopausal women, ER and PR concentrations were similarly correlated with AR levels. The PR, but not the ER concentration, was positively correlated to AR levels in benign breast tumors. These findings were confirmed by multiple regression, taking into consideration additional information about the patients to build statistical models allowing prediction of AR. Among the other variables considered in building these models--age, menopausal status, weight, height, and clinical stag...Continue Reading

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Citations

Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·M Di MonacoG Boccuzzi
Jan 1, 1996·Breast Cancer Research and Treatment·M BoydS A Bartow
Jan 1, 1990·Archives of Gynecology and Obstetrics·M LangerJ Spona
Apr 22, 2006·Virchows Archiv : an International Journal of Pathology·Walter SchippingerFarid Moinfar
Dec 6, 2008·Folia Histochemica Et Cytobiologica·Anil K AgrawalEwa Nienartowicz
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·G BoccuzziO Danni
Nov 11, 1992·International Journal of Cancer. Journal International Du Cancer·R E HallR L Sutherland
Jun 1, 1989·American Journal of Surgery·L M EllisK I Bland
Sep 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M M Brentani, E C Baracat
Mar 11, 1992·Critical Reviews in Oncology/hematology·D N Danforth
Sep 18, 2012·The Journal of Steroid Biochemistry and Molecular Biology·K M McNamaraH Sasano
Aug 1, 1994·Cancer·B S HulkaR A Lininger

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