PMID: 60232Jan 1, 1976Paper

Androgen of the human prostate

Endocrine Research Communications
W E Farnsworth, J R Brown

Abstract

The relationship between the concentrations of total and apparent free testosterone in the plasma and the levels of testosterone (T), dihydrotestosterone (DHT) and 5 alpha-androstan-3-alpha, 17 beta-diol (DIOL) in 13 benign hypertrophic and 6 carcinomatous prostates was studied. The androgen concentration within both types of glands was nearly 4-fold that in the blood but bore no direct relationship to the blood level. About 75% of the androgen in the tissue was DHT. The most striking finding was that, in spite of a 25.5% less concentrated pool of apparent free testosterone in the blood, the level of T and its metabolites in the cancer tissue was 29% above that in the samples of benign hypertrophic prostate.

References

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Citations

Jun 1, 1981·Journal of Steroid Biochemistry·R W Hudson
Aug 28, 2012·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·P EschwègeUNKNOWN les membres du CCAFU
Apr 1, 1988·British Journal of Urology·F LabrieN Bergeron
Dec 3, 2002·Nature Reviews. Cancer·Robert A Bok, Eric J Small
Sep 6, 2007·Journal of Cellular Biochemistry·Giuseppe Carruba
Jan 31, 2007·Annals of the New York Academy of Sciences·Giuseppe Carruba
Jan 1, 1978·Archives of Andrology·W E FarnsworthL M Lewandowski
Jan 1, 1979·The Journal of Urology·G Lieskovsky, N Bruchovsky

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