PMID: 16645434Apr 29, 2006Paper

Androgen receptor as a therapeutic target for androgen independent prostate cancer

American Journal of Therapeutics
Nima Sharifi, William L Farrar

Abstract

Prostate cancer is the leading cause of nonskin malignancy and the second leading cause of cancer death in men. Androgen deprivation therapy is the first-line of systemic therapy against advanced prostate cancer. All advanced prostate cancers eventually grow despite castrate levels of testosterone. We review the evidence that androgen independent prostate cancer continues to require androgen receptor activity for growth, the mechanisms of androgen receptor activation in the castrate setting, and possible points of intervention for novel therapies targeting the androgen receptor and prostate cancer.

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Citations

Dec 14, 2007·Cancer Chemotherapy and Pharmacology·Nima SharifiWilliam L Farrar
Apr 17, 2009·Cancer Causes & Control : CCC·Janet K Hess-Wilson
Sep 18, 2007·Medical Oncology·Victor ValdespinoPavel Pisa
Feb 9, 2007·Nature Clinical Practice. Urology·Eric C NelsonChristopher P Evans
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nima SharifiWilliam D Figg
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nima SharifiWilliam L Farrar
Jan 18, 2012·Critical Reviews in Oncogenesis·Qiang ZhangGuangchao Sui
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xu-Bao ShiRalph W deVere White
Oct 10, 2007·BJU International·Nima SharifiWilliam D Figg
Oct 16, 2019·Annual Review of Medicine·Richard J Auchus, Nima Sharifi
Aug 19, 2007·Molecular Cancer Therapeutics·Nima SharifiWilliam L Farrar
Dec 19, 2006·Molecular Cancer Therapeutics·Yelena B WetherillKaren E Knudsen

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