PMID: 9192502Jul 1, 1997Paper

Androgen-receptor blockade does not impair bone mineral density in adolescent females

Calcified Tissue International
S BertelloniG Saggese

Abstract

The effect of peripheral androgen hypersensitivity on bone mineral density (BMD) was investigated in a group of adolescent women with idiopathic hirsutism (n = 17; mean age 17.0 +/- 1.7 years). The effect of long-term androgen-receptor blockade with flutamide (500 mg daily in two divided doses for 12 months) on BMD was assessed too. BMD was measured at lumbar spine (L2-L4) by a dual energy X-ray densitometer. Before flutamide treatment, patient BMD (1.14 +/- 0.07 g/cm2) was not significantly different from that of the control group (1.16 +/- 0.12 g/cm2, n = 22), and was normal for age and sex (BMD 0.14 +/- 0.69 SDS, P = NS vs. 0). After 12 months of treatment, absolute BMD in patients increased (1.18 +/- 0.08 g/cm2, P < 0.002), but SDS BMD did not change (0.21 +/- 0.72, P = NS vs. baseline). Flutamide treatment determined a clinical, marked improvement of androgen hypersensitivity (Ferriman-Gallwey score: before 22.0 +/- 6.2; 6 months: 13.2 +/- 6.4, P < 0.003; 12 months; 7.6 +/- 4.1, P < 0. 001; acne score: before 3.8 +/- 0.8; 3 months 0.8 +/- 0.5, P < 0. 001; later disappeared). The serum levels of 3alpha-androstenediol-glucoronide decreased (before: 8.6 +/- 1.1 microg/liter; 12 months: 7.2 +/- 1.0 microg/liter, P < 0.02), whe...Continue Reading

Citations

Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L C HofbauerS Khosla
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M SowersM Jannausch
Jan 21, 2012·Journal of Pediatric and Adolescent Gynecology·Susanne BechtoldHeinrich Schmidt
Nov 11, 2008·Steroids·Bart L Clarke, Sundeep Khosla
Aug 5, 2005·Journal of Physiological Anthropology and Applied Human Science·Larisa A Scheplyagina, Tatyana Y Moisseyeva
Nov 4, 2016·Physiological Reviews·Maria AlmeidaStavros C Manolagas
Jun 8, 2004·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Oct 22, 1998·Neurology·F CosmanR Lindsay

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