Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population

Genetics and Molecular Research : GMR
J DangZ H Huo

Abstract

The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and 183 healthy controls from our hospital (Yinchuan, China). Repeat lengths were determined by fluorescent DNA fragment analysis using the ABI GeneScan software and DNA sequencing. We detected 17 short tandem repeat alleles in exon 1 in the Han population of Ningxia Province, China. The CAG repeat number ranged from 14 to 31 and the frequency ranged from 0.339 to 24.460%. Generally, (CAG)n repeat lengths <22 were classified as short (S), and those >22 were classified as long (L). No association was found between breast cancer and the S/L (CAG) variants. However, the frequency of the (CAG)25 repeats in the breast cancer group was significantly higher than that in the control group (P = 0.033, odds ratio = 1.790, 95% confidence interval = 1.044-3.069). These findings indicate a role for AR gene (CAG)n variations in breast cancer and might be informative for future genetic or biologi...Continue Reading

Citations

Mar 6, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Keely M McNamara, Hironobu Sasano
Jul 19, 2018·Journal of Nephrology·Danilo LofaroRenzo Bonofiglio
Apr 11, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Daniel A Landero-HuertaMargarita D Chávez-Saldaña

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