Androgen receptor identification in the diagnosis of eyelid sebaceous carcinomas

American Journal of Ophthalmology
Frederick A Jakobiec, Xiang Werdich

Abstract

To assess the role of androgen receptor detection in diagnosing eyelid sebaceous carcinomas and to compare it with that of adipophilin. Retrospective, clinicopathologic study. Ten sebaceous carcinomas (8 invasive, 2 intraepithelial only) were stained immunohistochemically for androgen receptors and were compared with adipophilin staining. Receptor staining also was performed on benign sebaceous tumors (a sebaceoma and an adenoma) and as controls on eyelid basal cell carcinomas, eyelid squamous cell carcinomas, conjunctival squamous dysplasias, and conjunctival melanomas. All 8 patients with an invasive component of sebaceous carcinoma underwent a biopsy in which the tumor cells showed diffusely positive results for androgen receptors (>20% of cells and usually >40%) and positive results for adipophilin. Eight cases displaying an intraepithelial (or pagetoid) component of spread also showed diffusely positive results for androgen receptors and adipophilin in at least 1 of multiple biopsy samples from each patient. However, in 8 of 21 separate conjunctival biopsy specimens with intraepithelial cytologic atypia, adipophilin results were negative. A sebaceoma and a sebaceous adenoma also showed positive results for both of these bi...Continue Reading

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Citations

Aug 12, 2014·Der Pathologe·A Böer-Auer
Nov 12, 2015·American Journal of Ophthalmology·Frederick A Jakobiec
Jan 23, 2015·Diagnostic Cytopathology·Deepali JainVenkateswaran K Iyer
Nov 18, 2015·Advances in Medicine·Ifeyinwa Mary OnwubuyaKevin Nwabueze Ezike
May 29, 2015·Ophthalmic Plastic and Reconstructive Surgery·Anna M Stagner, Frederick A Jakobiec
May 7, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Angel Fernandez-Flores, David S Cassarino
Dec 17, 2014·Ophthalmic Plastic and Reconstructive Surgery·Emma C DaviesMami A Iwamoto
May 3, 2020·Journal of Cutaneous Pathology·Shyam S RaghavanRyanne A Brown
Jul 26, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eva Janine SchmitzKarin U Loeffler
Jul 7, 2015·Asia-Pacific Journal of Ophthalmology·Jerry A ShieldsCarol L Shields
Apr 27, 2018·International Ophthalmology·Maria Vittoria Cicinelli, Swathi Kaliki
Jan 4, 2020·Eye·Lindsay A McGrathSachin M Salvi
Jan 23, 2021·Annales de dermatologie et de vénéréologie·F BourlondB Cribier
Oct 3, 2020·Ocular Oncology and Pathology·Frederick A JakobiecTatyana Milman

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