Androgen receptor modulation in benign human prostatic tissue and prostatic adenocarcinoma during neoadjuvant endocrine combination therapy

The Prostate
T H van der KwastF Labrie

Abstract

Modulation of androgen receptor (AR) expression during neoadjuvant endocrine therapy in human prostates of patients with localized prostate cancer was investigated by immunohistochemistry. In 8 of 15 untreated prostatectomy specimens, the majority of prostatic glandular cells displayed nuclear immunostaining for AR, whereas only 1 of 26 pretreated cases displayed a similar glandular AR expression. Expression of AR in the prostatic stromal compartment of nontreated cases proved to be quite heterogeneous, since 4 of the 15 (27%) examined specimens did not show stromal AR expression. After preoperative neoadjuvant therapy, this value was 68%, although this difference did not reach statistical significance. Prostatectomy specimens of the treated patients contained carcinomas with a higher Gleason score than those of untreated patients. AR expression in carcinomas of treated patients was diminished (P= 0.05), which may be attributed to their relatively lower differentiation grade. The data strongly suggest that neoadjuvant hormone therapy reduces AR expression by nonneoplastic prostatic glandular cells and carcinoma cells by a selective, but incomplete, elimination of AR-positive cells.

References

May 10, 1991·International Journal of Cancer. Journal International Du Cancer·T H van der KwastJ Trapman
Apr 1, 1991·Molecular and Cellular Endocrinology·A KrongradM J McPhaul
Jul 1, 1991·Molecular and Cellular Endocrinology·F Labrie
Jul 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J A Ruizeveld de WinterT H van der Kwast
May 31, 1991·Biochemical and Biophysical Research Communications·H TakedaC Chang
Apr 1, 1990·The Journal of Pathology·J A de WinterT H van der Kwast
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Bonkhoff, K Remberger

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Citations

Jan 26, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jun YangJames T Dalton
Mar 28, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Sylvain GauthierFernand Labrie
Jul 29, 2008·Cancer Letters·Hong-Lin Devlin, Maria Mudryj
May 13, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Bernard Têtu
Sep 1, 1996·The Journal of Urology·I G Kruithof-DekkerT H Van der Kwast
Jan 28, 2006·European Radiology·Tatsuro KaminagaIzumi Kimura
May 18, 2006·The International Journal of Cardiovascular Imaging·Ahmed AlsaileekJerome Breen
Feb 5, 2008·Journal of Thrombosis and Thrombolysis·M Azra TanrikuluMehmet Agirbasli
Mar 6, 2013·General Thoracic and Cardiovascular Surgery·Jun AmanoUichi Ikeda

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