Androgen receptor promotes esophageal cancer cell migration and proliferation via matrix metalloproteinase 2

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yi ZhangCai Cheng

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. Androgen receptor (AR) plays an important role in many kinds of cancers. However, the molecular mechanisms of AR in ESCC are poorly characterized. In the present study, Western blot analysis and real-time quantitative PCR were performed to identify differentially expressed AR in 40 ESCC tissue samples, which revealed that the messenger RNA (mRNA) and protein expression of AR is upregulated in the ESCC tissue samples. AR overexpression induced increases in ESCC cell invasion and proliferation in vitro. Silencing of AR inhibited the proliferation of KYSE450 cells which have a relatively high level of AR, and the invasion of KYSE450 cells was distinctly suppressed. Furthermore, AR knockdown led to substantial reductions in matrix metalloproteinase 2 (MMP2) and p-AKT levels in ESCC cell lines, but no significant change in AKT and MMP9 expression. These results suggest that AR is involved in tumor progression, and thus, AR could represent selective targets for the molecularly targeted treatments of ESCC.

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Citations

Oct 21, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shao-Hua Xie, Jesper Lagergren
Oct 16, 2015·BMC Cancer·Yabing ZhengXiaotian Chang
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rong LiCan-Xia Xu
Dec 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhan ShiXiaoqing Sun
Nov 13, 2019·Pharmacoepidemiology and Drug Safety·John BusbyChris R Cardwell
Mar 28, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hesham MohamedJaana Hagström
Mar 31, 2021·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Nahid Hashemi MadaniReza Malekzadeh
Sep 18, 2018·Cancer Letters·Daoshan ZhengZhaoyu Li

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