Abstract
Androgen-deprivation therapy has been the standard treatment for metastatic and locally advanced prostate cancer, but the majority of patients will progress to castration-resistant prostate cancer within 2-3 years. Unlike the case in breast cancer, no clinically validated biomarker has been used to predict the outcomes of androgen-deprivation therapy. To evaluate androgen-receptor splice variant-7 (AR-V7) detection in newly diagnosed advanced prostate cancer and describe the distinctive prognosis of this novel molecular subtype, this study retrospectively enrolled 168 newly diagnosed prostate cancer patients from 2003 to 2015 who received androgen-deprivation therapy. AR-V7 immunohistochemical staining was performed with a monoclonal antibody, and AR-V7 expression was determined using Immune-Reactive Score data. The association between nuclear AR-V7 expression and prognosis was determined. Multiple cause-specific Cox regression and stratified cumulative incidences were used to analyze the prognosis risk. Among the 168 patients, 32 (19%) were AR-V7-positive. Compared with the AR-V7-negative patients, the AR-V7-positive patients had significantly lower prostate-specific antigen response rates (P<0.001) to androgen-deprivation the...Continue Reading
References
Jul 1, 1972·CA: a Cancer Journal for Clinicians·C Huggins, C V Hodges
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maha HussainUNKNOWN Southwest Oncology Group Trial 9346 (INT-0162)
Jul 3, 2008·Cancer Research·Scott M DehmDonald J Tindall
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jan 2, 2009·Cancer Research·Rong HuJun Luo
Feb 10, 2009·Nature Clinical Practice. Urology·William P HarrisBruce Montgomery
Feb 27, 2009·Cancer Research·Zhiyong GuoYun Qiu
Jul 21, 2010·The Journal of Clinical Investigation·Shihua SunStephen R Plymate
Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Philip A WatsonCharles L Sawyers
Mar 30, 2011·The Prostate·Rong HuJun Luo
May 10, 2011·PloS One·Emma HörnbergPernilla Wikström
Nov 25, 2011·PloS One·Xiaotun ZhangStephen R Plymate
Jun 15, 2012·European Urology·Atish D ChoudhuryTapio Visakorpi
Jan 1, 2013·BMC Cancer·Pier Vitale NuzzoFrancesco Boccardo
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
Sep 4, 2014·The New England Journal of Medicine·Emmanuel S AntonarakisJun Luo
Jan 8, 2015·Scientific Reports·Yuanyuan QuGuohai Shi
Jul 17, 2015·JAMA Oncology·Emmanuel S AntonarakisJun Luo
Jul 21, 2015·European Urology·Wendy OnstenkStefan Sleijfer
Feb 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I ScherUNKNOWN Prostate Cancer Clinical Trials Working Group 3
Apr 28, 2016·European Urology·Jonathan WeltiStephen R Plymate
Citations
May 5, 2018·Advances in Anatomic Pathology·Jane Kim Nguyen, Cristina Magi-Galluzzi
Oct 20, 2018·The Journal of Clinical Investigation·Adam SharpStephen R Plymate
Sep 11, 2019·The Prostate·Jordan E VellkyWilliam A Ricke
Dec 7, 2019·Scandinavian Journal of Urology·Hyung Kyu ParkGhee Young Kwon
Sep 12, 2018·Diagnostics·Arlou Kristina AngelesHolger Sültmann
Sep 28, 2018·Cancers·Namrata Khurana, Suresh C Sikka
Apr 28, 2019·International Journal of Molecular Sciences·Namrata Khurana, Suresh C Sikka
May 15, 2019·Medicine·Alessandro SciarraMartina Maggi
May 12, 2020·Cancer Cell International·Zhize WangLiping Xie
Aug 2, 2019·Medicines·Ugo TestaElvira Pelosi
Mar 7, 2020·Prostate Cancer and Prostatic Diseases·Changxue LuJun Luo
Aug 9, 2019·Oncogene·Yangjun ZhangHua Xu
Sep 20, 2020·Cancers·Paul KönigVerena Lieb
Sep 14, 2018·The World Journal of Men's Health·Kazutoshi Fujita, Norio Nonomura
Oct 29, 2020·The Journal of Experimental Medicine·Min MaG Paolo Dotto
Jan 23, 2021·Cancers·Xiangyu LiAdil Mardinoglu
Feb 14, 2021·European Urology·Heng LiHua Xu
Feb 1, 2021·Cancer Treatment and Research Communications·Adam G SowalskyStephen R Plymate
Apr 2, 2021·Biomarker Research·Wei OuyangZhangqun Ye
Jul 29, 2021·Journal of Cell Science·Fatma ÖzgünNathan A Lack
Jan 20, 2020·Urologia Internationalis·Holger Hans Herman ErbChristian Thomas