Androgen receptors and skeletal muscle composition in trotters treated with nandrolone laureate

Zentralblatt für Veterinärmedizin. Reihe A
S HyyppäA R Pösö

Abstract

To study the effects of nandrolone laureate (19-nortestosterone) on muscle hypertrophy and concentration of androgen receptors (AR), biopsy specimens were taken from the middle gluteal muscle of 6 Finnhorse trotters (geldings and mares) undergoing training before, immediately after, and 13 weeks after a 14-week treatment with nandrolone. Another 6 similarly trained horses served as controls. An additional 10 mares and 10 geldings were used to study annual variation in muscle concentration of AR. AR was immunohistochemically localized in the nuclei. AR concentration remained constant during the first 14 weeks of the study, but increased significantly during the 13-week follow-up period in both groups. This finding can be explained by the annual variation in AR. In the anabolic steroid (AS)-treated horses, but not in the controls (C), the cross-sectional area of the type I fibres increased significantly during the treatment period, and the percentage of type IIA fibres correlated positively with AR concentration at the end of nandrolone treatment. In the AS group, the concentration of DNA decreased during the 13-week follow-up period, and the percentage of H-chains in the isoenzymes of LDH increased. Protein concentration increas...Continue Reading

References

Jan 15, 1979·Analytical Biochemistry·C F BrunkT W James
Oct 1, 1975·Acta Physiologica Scandinavica·B EssénB Saltin
Nov 1, 1976·Journal of Steroid Biochemistry·O JanneR Vihko
Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·F Celotti, P Negri Cesi
Mar 1, 1991·Journal of Applied Physiology·A SaboridoA Megías
Jun 1, 1990·Medicine and Science in Sports and Exercise·R C HicksonA P Young
Jan 1, 1989·Annual Review of Physiology·F G Berger, G Watson
Nov 1, 1987·Pflügers Archiv : European journal of physiology·S Egginton
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jul 1, 1982·Equine Veterinary Journal·D H SnowM A Nimmo
Dec 1, 1993·The Veterinary Clinics of North America. Equine Practice·D H Snow
Aug 1, 1993·Pflügers Archiv : European journal of physiology·E van BredaJ F Glatz
Feb 1, 1993·Annals of Medicine·O A JänneM Mehto
May 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M C LinN F González-Cadavid

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Citations

Apr 6, 2004·Atherosclerosis·Peter Alexandersen, Claus Christiansen
Dec 3, 2015·Journal of Cellular Physiology·Cristoforo PomaraEmanuela Turillazzi
Sep 14, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S Hyyppä
Dec 10, 1999·Medicine and Science in Sports and Exercise·F KadiL E Thornell
Oct 11, 2005·Journal of Proteome Research·Marc-Emmanuel DumasAlain Paris

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