Androgen receptors in Purkinje neurons are modulated by systemic testosterone and sexual training in a region-specific manner in the male rat

Physiology & Behavior
Miguel Perez-PouchoulenJorge Manzo

Abstract

The androgen receptor (AR) is a widely distributed molecule indicating the spread actions of its ligand steroid, and plays an important role underlying male sexual behavior. Nevertheless, the influence of steroid hormones and their receptors on cerebellar neurons, as foundation of sexual behavior, is largely unknown. We sought to determine the influence of peripheral hormones on the AR expression in Purkinje neurons across cerebellar lobules in the vermis of male rats. First, we found a basal AR expression in Purkinje neurons that was higher in the superficial region than the deep region only in cerebellar lobules 2, 4, 5, 7, 8 and 9. Moreover, only the cerebellar lobule 10 showed a significant difference between the coordinates 0.1, 0.3 and 0.9. Second, males with four sessions of sexual training showed a decreased AR density in cerebellar lobules 7, 8, 9 and 10, but not in lobules 2, 4 or 5 when compared to males with one session of sexual training. However, sexual training did not affect AR expression in Purkinje neurons according to their location in any of the cerebellar lobules studied. Third, castration decreased the AR density in the cerebellar lobules 1, 2, 5 and 9 in the superficial region, while in the deep region al...Continue Reading

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Citations

Jul 18, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Miguel Perez-PouchoulenJorge Manzo
Oct 30, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·D Hernández-MartínezM L López-Meraz
Apr 25, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Radwa BarakatCheMyong Ko
Jul 5, 2019·Archives of Sexual Behavior·Wendy Verónica Herrera-MoralesLuis Núñez-Jaramillo
Jun 6, 2021·Frontiers in Neuroendocrinology·Miriam PillerováĽubomíra Tóthová

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