Androgen regulation of corticotropin-releasing hormone receptor 2 (CRHR2) mRNA expression and receptor binding in the rat brain.

Experimental Neurology
Michael J WeiserRobert J Handa

Abstract

Stress-induced affective disorders, such as depression and anxiety, are more prevalent in females than in males. The reduced vulnerability to these disorders in males may be due to the presence of androgens, which are known to dampen the stress response and reduce anxiety-like behaviors. However, a neurobiological mechanism for this sex difference has yet to be elucidated. Corticotropin-releasing hormone receptor 2 (CRHR2) has been implicated in regulating anxiety-type behaviors and is expressed in stress-responsive brain regions that also contain androgen receptors (AR). We hypothesized that androgen may exert its effects through actions on CRHR2 and we therefore examined the regulation of CRHR2 mRNA and receptor binding in the male rat forebrain following androgen administration. Young adult male Sprague/Dawley rats were gonadectomized (GDX) and treated with the non-aromatizable androgen, dihydrotestosterone propionate (DHTP) using hormone filled Silastic capsules. Control animals received empty capsules. Using quantitative real-time RT-PCR, CRHR2 mRNA levels were determined in block-dissected brain regions. DHTP treatment significantly increased CRHR2 mRNA expression in the hippocampus, hypothalamus, and lateral septum (p<0....Continue Reading

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Citations

Oct 1, 2013·Frontiers in Neuroendocrinology·Jenna McHenryMohamed Kabbaj
Nov 20, 2013·Frontiers in Neuroendocrinology·Robert J Handa, Michael J Weiser
Jun 12, 2013·Hormones and Behavior·Jaylyn WaddellMargaret M McCarthy
Sep 15, 2014·Experimental Neurology·Nadine Provençal, Elisabeth B Binder
Oct 12, 2013·The Journal of Comparative Neurology·Jill M WeathingtonBradley M Cooke
Oct 25, 2016·Hormones and Behavior·Catherine T ClinardMatthew A Cooper
Apr 29, 2018·Molecular Neurobiology·Birgit LudwigYogesh Dwivedi
May 24, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Luis Ezequiel GallolFabian Heber Mohamed
Jul 31, 2020·Biology of Sex Differences·Damian G ZuloagaRobert J Handa
Sep 26, 2015·Nature Neuroscience·Tracy L Bale, C Neill Epperson

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