Androgen regulation of JM-27 is associated with the diseased prostate

Journal of Andrology
Uzma S ShahRobert H Getzenberg

Abstract

Despite intense research efforts, the etiology of prostatic hyperplasia associated with both benign prostatic hyperplasia (BPH) and prostate cancer remains poorly understood. Our previous studies using array technology identified JM-27 as a transcript that is dramatically up-regulated in the prostates of patients with symptomatic BPH and in normal, adjacent prostatic regions of patients with prostate cancer. In the present study, using an extended sample set, we show a correlation between the messenger RNA and protein expression of JM-27. To investigate the possible functions of this gene, its expression in the rat prostate was examined by immunoblot analysis using a polyclonal antibody specific to human JM-27. This antibody reacts with 2 rat polypeptides of 17 kd and 27 kd in size. Whereas the 27-kd form of the JM-27 protein found in human prostate is selectively expressed in the dorsolateral lobes of the rat prostate, the 17-kd form is expressed only in the ventral lobe. Expression of both forms of this protein appears to be androgen-regulated. There is a time-dependent decrease in expression of the protein products in the ventral and dorsolateral lobes of the rat prostate after castration. Administration of exogenous testost...Continue Reading

References

Oct 22, 1998·Biology of Reproduction·P P BanerjeeT R Brown
Mar 29, 2002·The Prostate·Judith A WubahCharles J Bieberich
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kulkarni PrakashRobert H Getzenberg
Aug 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter S NelsonBiaoyang Lin
Mar 21, 2003·Developmental Biology·Paul C MarkerGerald R Cunha
Apr 17, 2003·Endocrinology·Elisabetta BaldiGianni Forti

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Citations

Jun 11, 2005·The Journal of Urology·Cynthia H Minnery, Robert H Getzenberg
Feb 19, 2008·The Journal of Urology·Chris MullinsUNKNOWN MPSA Consortium
Jan 20, 2019·Journal of Experimental & Clinical Cancer Research : CR·Chengcheng LvYu Zeng

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