Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss

F1000Research
R D SinclairL Jones

Abstract

The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning.  The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche.  The arrector pili muscle has been previously thought to be merely a bystander and not to have an active role in hair disease. Computer generated 3D reconstructions of the arrector pili muscle have helped explain why women with androgenetic alopecia (AGA) experience diffuse hair loss rather than the patterned baldness seen in men.  Loss of attachment between the bulge stem cell population and the arrector pili muscle also explains why miniaturization is irreversible in AGA but not alopecia areata. A new model for the progression of AGA is presented.

References

Sep 25, 1998·BMJ : British Medical Journal·R Sinclair
Oct 31, 2003·Expert Reviews in Molecular Medicine·Justine A EllisStephen B Harrap
Jul 29, 2004·Journal of the American Academy of Dermatology·Rodney SinclairJill Magee
Dec 31, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Desmond C C Gan, Rodney D Sinclair
Oct 13, 2006·The British Journal of Dermatology·A G Messenger, R Sinclair
Mar 4, 2014·The British Journal of Dermatology·N TorkamaniR Sinclair
Sep 12, 2014·International Journal of Trichology·Niloufar TorkamaniRodney D Sinclair
Apr 29, 2015·The British Journal of Dermatology·R Sinclair

❮ Previous
Next ❯

Citations

Apr 19, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·L BaoY Li
Sep 4, 2020·Dermatologic Therapy·Sonia Sofia Ocampo-GarzaAlessia Villani
Jun 23, 2019·Clinical Drug Investigation·Qian QuZhiqi Hu
Sep 22, 2016·Stem Cells and Development·Parvaneh MohammadiNasser Aghdami
Apr 25, 2021·Journal of Cosmetic Dermatology·Daniel Fernandes MeloCarlos Baptista Barcaui
Jun 1, 2021·Dermatologic Clinics·Alana KurttiKumar Sukhdeo
Aug 26, 2021·Veterinary Dermatology·Anneliese Willems, Rodney Sinclair

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.