PMID: 6403052Apr 5, 1983Paper

Androgenic stimulation of endocytosis, amino acid and hexose transport in mouse kidney cortex involves increased calcium fluxes

Biochimica Et Biophysica Acta
A GoldstoneC Lu

Abstract

Testosterone was previously shown to induce an early (less than 1 min) receptor-dependent stimulation of endocytosis, hexose and amino acid transport in mouse kidney cortex (Koenig, H., Goldstone, A. and Lu, C.Y. (1982) Biochem. Biophys. Res. Commun. 104, 165-172). Testosterone (10(-8) M) has now been found to stimulate rapidly (less than 30 s) the influx and efflux of 45Ca2+ in cortex slices. Testosterone also decreased mitochondrial 45Ca and augmented soluble 45Ca, indicating a mobilization of intracellular calcium. Incubation of cortex slices in calcium-free medium without or with 2.5 mM EGTA decreased basal endocytosis, hexose and amino acid transport and blocked the hormonal response. 100 microM verapamil blocked the hormonal response without affecting basal transport. The calcium ionophore A23187 rapidly stimulated endocytosis, hexose and amino acid transport. These data indicate that androgenic stimulation of membrane transport functions involves an increased influx of extracellular calcium and a mobilization of intracellular calcium. Increased cytosolic Ca2+ is probably the regulatory signal for these transport processes.

References

Jan 1, 1975·Journal of Steroid Biochemistry·C R ParkerV B Mahesh
Sep 1, 1976·European Journal of Biochemistry·C SchudtD Pette
Oct 1, 1972·The Journal of Cell Biology·R M Steinman, Z A Cohn
Feb 15, 1974·Science·B W O'Malley, A R Means
Oct 1, 1980·The Journal of Cell Biology·B Ceccarelli, W P Hurlbut
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D S KelleyV R Potter
Jan 15, 1982·Biochemical and Biophysical Research Communications·A GoldstoneC Lu
May 31, 1982·Biochemical and Biophysical Research Communications·H KoenigC Y Lu

❮ Previous
Next ❯

Citations

Jun 1, 1993·In Vitro Cellular & Developmental Biology. Animal·C D Kochakian, A A Welder
Jan 1, 1987·Journal of Steroid Biochemistry·L M Garcia-SeguraF Naftolin
Jan 1, 1990·Biology of the Cell·L R Mata, J F David-Ferreira
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H KoenigC Y Lu
Nov 1, 1984·British Journal of Pharmacology·P JohanssonL Nässberger
Jun 1, 1993·In Vitro Cellular & Developmental Biology. Animal·C D Kochakian, A A Welder
Jan 1, 1991·Progress in Biophysics and Molecular Biology·C I Cheeseman
Jul 14, 2004·Molecular and Cellular Endocrinology·Denis CouchourelMichèle G Brunette
Nov 15, 1983·Biochemical and Biophysical Research Communications·H KoenigC Y Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.