Androgens and the ageing male and female

Best Practice & Research. Clinical Endocrinology & Metabolism
Maria A Yialamas, Frances J Hayes

Abstract

Androgens play a number of important physiological roles in the human. In the male, testosterone is required for virilization, normal sexual function, and both stimulation and maintenance of bone and muscle mass. Epidemiological studies have shown a progressive decline in testosterone levels with ageing in men. The clinical significance of this decline is still unclear, and there is controversy as to whether a specific syndrome of androgen deficiency or 'andropause' exists. The benefits of testosterone supplementation in this age group have yet to be equivocally established, and long-term safety data on testosterone administration in this setting are lacking. In the female, a decline in testosterone levels with ageing has been less clearly established due, at least in part, to the absence of sensitive assays. Available data suggest that the major role of testosterone replacement after menopause may be in those women who have had an oophorectomy.

Associated Clinical Trials

Sep 19, 2005·Alvin M. Matsumoto, MD, Alvin M. Matsumoto, MD

References

Dec 1, 1976·Clinical Obstetrics and Gynecology·H L Judd
Oct 2, 1976·British Medical Journal·S ChakravartiJ W Studd
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·L S MyersJ M Davidson
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·A GrayC Longcope
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S G KorenmanD Garza
Feb 1, 1989·The Journal of Clinical Endocrinology and Metabolism·C B SheckterW J Bremner
Oct 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J S FinkelsteinW F Crowley
Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J S TenoverW J Bremner
May 1, 1988·Clinical Endocrinology·J D SantamariaJ A Fleetham
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J C Cohen, R Hickman
Dec 1, 1986·The Journal of Clinical Endocrinology and Metabolism·H R Nankin, J H Calkins
Jan 15, 1985·American Journal of Obstetrics and Gynecology·B B Sherwin, M M Gelfand
Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R RubensA Vermeulen
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·H L Judd, S S Yen
Apr 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A VermeulenL Verdonck
Dec 1, 1983·The Journal of Clinical Investigation·J D VeldhuisM L Johnson
Jun 1, 1983·Metabolism: Clinical and Experimental·C H ChesnutD J Baylink
Oct 1, 1984·The Journal of Clinical Endocrinology and Metabolism·W B NeavesC S Petty
Nov 1, 1984·Metabolism: Clinical and Experimental·S J WintersP Troen
Jul 27, 1984·JAMA : the Journal of the American Medical Association·B F HurleyA P Goldberg
Dec 1, 1980·The Journal of Clinical Endocrinology and Metabolism·P J Snyder, D A Lawrence
Oct 1, 1982·The Journal of Clinical Endocrinology and Metabolism·E NieschlagE J Wickings
Mar 3, 1983·The New England Journal of Medicine·R E SandblomD J Pierson
Jun 1, 1983·The Journal of Clinical Endocrinology and Metabolism·W J BremnerP N Prinz
Nov 1, 1995·Progress in Cardiovascular Diseases·C J Bagatell, W J Bremner
Jul 4, 1996·The New England Journal of Medicine·S BhasinR Casaburi
Nov 28, 1997·Clinical Endocrinology·D J HandelsmanA J Conway
Aug 27, 1998·The New England Journal of Medicine·J P BilezikianM M Grumbach
Mar 31, 1999·European Journal of Endocrinology·L C Hofbauer, S Khosla
Sep 7, 2000·The New England Journal of Medicine·J L ShifrenN A Mazer
Dec 29, 2000·Menopause : the Journal of the North American Menopause Society·S R DavisB J Strauss

❮ Previous
Next ❯

Citations

Oct 19, 2004·The Nurse Practitioner·Anne Katz
Jan 20, 2012·BMC Cancer·Jay H FowkeDaniel A Barocas
Dec 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Valeria VastaJoseph A Beavo
Jul 1, 2010·Journal of Advanced Pharmaceutical Technology & Research·Peeyush KumarAjay Patidar
Jun 15, 2010·The Lancet Oncology·Antonio ViganoRobert Kilgour
Jul 19, 2005·Annals of the New York Academy of Sciences·Anna Ratka
Apr 10, 2007·Seminars in Nuclear Medicine·David WellDrew A Torigian
Jan 1, 2010·Hormone Molecular Biology and Clinical Investigation·Martina ReiterHeinrich H D Meyer
Feb 3, 2015·Environmental Science and Pollution Research International·Nichrous MlalilaAskwar Hilonga
Jan 8, 2015·Frontiers in Endocrinology·Carla Basualto-AlarcónManuel Estrada
Sep 29, 2005·Drug Delivery·Denize Ainbinder, Elka Touitou
May 30, 2009·American Journal of Men's Health·Yuk Yee Yan
Feb 10, 2019·Journal of Clinical Medicine·Yu Seob Shin, Jong Kwan Park
Feb 27, 2019·Current Osteoporosis Reports·Robert J PignoloAbhishek Chandra
Jan 30, 2009·Experimental Biology and Medicine·Anna RatkaJames Simpkins
Mar 4, 2015·The American Journal of Clinical Nutrition·L Claudia PopSue A Shapses
Jun 6, 2020·Frontiers in Endocrinology·Genaro BarrientosManuel Estrada
Mar 21, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Berna C Özdemir, Gian-Paolo Dotto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.