Androgens in the hippocampus can alter, and be altered by, ictal activity

Pharmacology, Biochemistry, and Behavior
M E Rhodes, C A Frye

Abstract

Steroid hormones, such as androgens, can modulate seizure processes. This review summarizes prior research and presents new data that support the role of androgens in modulating seizure processes. Testosterone, the primary endogenous androgen, has antiseizure effects in people and in animal models of epilepsy. Furthermore, testosterone's antiseizure effects may involve actions of its 5alpha-reduced metabolite and neuroactive steroid, 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). The hippocampus is a target for androgen action and is involved in many types of seizure disorder. Data suggest that actions of androgens in the hippocampus may be important for androgens' antiseizure effects. Interestingly, there may also be a reciprocal relationship between androgens and seizures. Ictal activity can alter the gonadal responsiveness of people with epilepsy and in animal models of seizure disorder. Thus, this paper will review data in support of androgens' antiseizure effects. Further understanding of androgens' role in seizure processes is important for potential therapeutic effects.

References

Jun 1, 1991·Physiology & Behavior·J Thomas, J H McLean
Jan 1, 1991·Epilepsia·M J Morrell
Apr 1, 1986·Archives of Neurology·A G HerzogN Geschwind
Feb 1, 1970·The American Journal of Psychiatry·D Blumer
Jan 1, 1970·Pharmacology·W E Stone
Jan 1, 1984·Behavioral and Neural Biology·K C Chambers, C H Phoenix
Jul 1, 1981·Neurology·E W LothmanJ A Ferrendelli
Dec 1, 1994·Pharmacology & Toxicology·M E PesceH F Miranda
Aug 8, 1998·Psychoneuroendocrinology·C A Frye, T A Reed
Aug 12, 2000·Stress : the International Journal on the Biology of Stress·C A Frye, C M McCormick
Dec 7, 2002·Cognitive, Affective & Behavioral Neuroscience·C A Frye, A M Seliga
Apr 1, 2004·Brain Research·Madeline E RhodesCheryl A Frye
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Kassandra L EdingerCheryl A Frye

❮ Previous
Next ❯

Citations

Nov 23, 2005·Behavioral Neuroscience·Juan Carlos JorgeCarmen S Maldonado-Vlaar
Jun 1, 2014·The Veterinary Journal·Sofie A E Van MeervenneLuc M L Van Ham
Aug 11, 2010·Journal of Chemical Neuroanatomy·Sedat MeydanMustafa Sarsılmaz
Feb 28, 2016·Biochemical and Biophysical Research Communications·Satoshi EndoAkira Ikari
Oct 27, 2009·Neurologic Clinics·Page B Pennell
Mar 24, 2009·Epilepsy & Behavior : E&B·Page B Pennell, Pamela Thompson
May 12, 2009·Frontiers in Neuroendocrinology·Christian J PikeAnna M Barron
Jan 29, 2008·Hormones and Behavior·Christian J PikeEmily R Rosario
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye, Kassandra L Edinger
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Kassandra L EdingerCheryl A Frye
Nov 14, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W WangD Zhou
Aug 2, 2005·Epilepsy & Behavior : E&B·Madeline E RhodesCheryl A Frye
Mar 26, 2013·Acta Physiologica Hungarica·Mahmoud HosseiniM Soukhtanloo
Oct 27, 2009·Seizure : the Journal of the British Epilepsy Association·Mahmoud HosseiniAli Gorji
Mar 26, 2005·Current Opinion in Neurology·Andrew G Herzog, Kristen M Fowler
Dec 24, 2018·Journal of Veterinary Internal Medicine·Johanna A ForsgårdTarja S Jokinen
Sep 29, 2019·Frontiers in Neuroendocrinology·Laurence MeyerAyikoe-Guy Mensah-Nyagan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.