Apr 1, 1988

Androphilic protein studied histochemically in stage D2 prostatic cancer

K YamaguchiJ S Ki


Androphilic protein in prostatic cancer was histochemically observed with dihydrotestosterone (DHT), R 1881, and mibolerone as ligands. Cancer cells were equally stained with fluorescent R 1881 and mibolerone, and this fluorescence seems to be made up of both the androgen receptor and progestin-binding protein. The staining with fluorescent DHT was weak. Sixty-two Stage D2 prostatic cancer patients were examined with histochemical androphilic protein, and they then received endocrine therapy. The presence of fluorescence of R 1881 was not correlated with grade, but a relationship between the presence of fluorescence and the response to endocrine therapy was noticed 6 months after the start of treatment. Moreover, fluorescence-positive patients showed better survival than fluorescence-negative patients. An examination with fluorescent DHT revealed a similar tendency to that of R 1881, but the frequency of positive fluorescence was lower, indicating that R 1881 is a suitable ligand in this type of study.

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Mentioned in this Paper

Prostatic Neoplasms
Androgen Receptor
Dihydrotestosterone Assay
TNM Staging System
Endocrine therapy antineoplastic AND immunomodulating agents
AR protein, human
Plasma Protein Binding Capacity

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