Androstenedione and its conversion to plasma testosterone in congenital adrenal hyperplasia

The Journal of Clinical Investigation
R Horton, S D Frasier

Abstract

The plasma concentration, production rate, and conversion ratio of androstenedione and testosterone were studied in seven children with congenital adrenal hyperplasia (CAH) of the 21-hydroxylase type. Plasma androstenedione and testosterone measured by double isotope derivative assay and estimated blood production rates were manyfold increased in the untreated state, markedly suppressed with glucocorticoid, and increased after the administration of ACTH. The metabolic clearance rate when corrected for body size and the conversion ratio of androstenedione to testosterone were similar to previously determined values in normal adults. Consideration of the androgen concentrations and conversion ratios indicates that in children with CAH, 76% of the plasma testosterone in prepubertal females and 36% in males are derived from peripheral conversion of blood androstenedione. The calculated amount of testosterone unaccounted for by peripheral conversion is similar to normal prepubertal values. This approach indicates that virilization in these children results from increased levels of testosterone but that the major source in CAH of this potent androgen is androstenedione secreted by the adrenal cortex.

References

Jan 1, 1967·The Journal of Clinical Endocrinology and Metabolism·R Horton, J F Tait
Mar 1, 1966·The Journal of Clinical Endocrinology and Metabolism·C W LloydR E Batt
Oct 21, 1965·The New England Journal of Medicine·W S Coppage, A E Cooner
Sep 1, 1965·The Journal of Clinical Endocrinology and Metabolism·R Horton
Aug 1, 1966·The Journal of Clinical Endocrinology and Metabolism·A M Camacho, C J Migeon
May 1, 1966·The Journal of Clinical Endocrinology and Metabolism·J A Resko, K B Eik-nes
Jul 1, 1963·The Journal of Clinical Endocrinology and Metabolism·A RIONDELB LITTLE
Mar 1, 1963·The Journal of Clinical Endocrinology and Metabolism·A M CAMACHO, C J MIGEON
Nov 1, 1964·The Journal of Clinical Investigation·S G KORENMAN, M B LIPSETT
Mar 1, 1965·The Journal of Clinical Endocrinology and Metabolism·R P ZURBRUEGGL I GARDNER
Jun 1, 1965·The Journal of Clinical Endocrinology and Metabolism·S G KORENMANM B LIPSETT
May 1, 1965·The Journal of Clinical Endocrinology and Metabolism·N Y LIM, J F DINGMAN

❮ Previous
Next ❯

Citations

Mar 1, 1979·Archives of Sexual Behavior·H F Meyer-Bahlburg
May 1, 1972·Metabolism: Clinical and Experimental·L S LevineR E Peterson
Sep 28, 1967·The New England Journal of Medicine·O GoldsmithR Horton
Jul 25, 1985·The New England Journal of Medicine·F KuttennI Mowszowicz
Mar 1, 1970·Acta paediatrica Scandinavica·O M GalalB T Rudd
Aug 1, 1973·Archives of Disease in Childhood·B T RuddC G Theodoridis
May 1, 1981·Postgraduate Medical Journal·A D WrightB T Rudd
Aug 1, 1977·The Journal of Clinical Investigation·D L HemsellP C MacDonald
Jan 1, 1980·Pharmacology & Therapeutics·G Telegdy
May 1, 1980·Current Problems in Pediatrics·R L RosenfieldT D Allen
Jun 1, 1980·Clinical Endocrinology·C Lejeune-LenainJ R Franckson
Oct 1, 1979·Clinical Endocrinology·D F ChildD C Anderson
Jan 1, 1979·American Journal of Medical Genetics·E S MarcusV M Riccardi
Jul 1, 1972·Metabolism: Clinical and Experimental·M A Kirschner, C W Bardin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved