Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
P R Blackett MD, D A Freeman MD

Abstract

To report two cases of gynecomastia that occurred in boys with 11beta-hydroxylase and 21-hydroxylase deficiency. We describe the physical findings and summarize the laboratory evaluation and treatment of two cases encountered in our medical practice. Both of our patients (a 4-year-old boy and a 17-year-old boy) had extreme virilization and gynecomastia; on laboratory assessment, androstenedione and estrogen levels were high. Treatment with hydrocortisone was recommended. Peripheral conversion of adrenal androgen to estrogen likely caused the feminizing syndrome in these patients.

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Citations

Jul 16, 2008·Current Opinion in Pediatrics·Nina S Ma, Mitchell E Geffner
Nov 10, 2007·European Journal of Pediatrics·Malgorzata WasniewskaFilippo De Luca
Jul 29, 2009·Journal of Endocrinological Investigation·M WasniewskaF De Luca
Dec 29, 2020·Clinical Case Reports·George R ThompsonAlex Odermatt

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