Androstenedione production by malignant epithelial ovarian tumors

Gynecologic Oncology
C G MählckO Kjellgren

Abstract

The concentration of plasma androstenedione in women with malignant epithelial ovarian tumors is investigated. Fifty-one postmenopausal and/or oophorectomized women with no other malignant or endocrine disease are included in the study. All FIGO stages and the histologic types I C, II C, III C, and IV are represented. The tumor volumes were evaluated once a month using bimanual rectovaginal palpation under anesthesia. Four blood samples were drawn for androstenedione radioimmunoassay at monthly intervals. The plasma levels were compared with those of a control group of postmenopausal women and a control group of fertile women in the follicular phase of the menstrual cycle. The results show a relationship between tumor volume and plasma androstenedione level. Histologic type and FIGO stage seem to be of subordinate importance and secondary to tumor volume. During chemotherapy the plasma concentration of androstenedione decreased parallel to the reduction in tumor volume. The initial plasma androstenedione concentration seems to have prognostic importance.

References

Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·C G MählckO Kjellgren
Jan 1, 1985·Acta Obstetricia Et Gynecologica Scandinavica·C G MählckG Selstam
Aug 1, 1974·The Journal of Clinical Endocrinology and Metabolism·G E Abraham
Jan 15, 1966·American Journal of Obstetrics and Gynecology·E J PlotzA A Stein
Jan 1, 1982·Acta Obstetricia Et Gynecologica Scandinavica·S JeppssonG Rannevik

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Citations

Mar 23, 2000·International Journal of Cancer. Journal International Du Cancer·M H AhonenP Tuohimaa
Apr 1, 1997·Endocrine·A Chamson-ReigC Libertun
Oct 23, 2009·Journal of Ovarian Research·Kesmic A JacksonK Sean Kimbro
Feb 1, 1989·Gynecologic Oncology·L G PoelsG Mungyer
Apr 16, 2002·British Journal of Cancer·R J EdmondsonB R Davies
Apr 11, 2001·Endocrine Reviews·N AuerspergP C Leung
Mar 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F ManeschiM Napoli
Sep 1, 1994·Endocrine Pathology·Fattaneh A Tavassoli

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