Anemia and aging: an overview of clinical, diagnostic and biological issues

Blood Reviews
R Carmel

Abstract

Anemia, usually mild, is one of the more common problems of the aged, especially in men. Although the anemia is often multifactorial, the specific entities can be grouped into three broad categories: (a) anemias due to causes more common in the elderly; (b) anemias without special predilection for the elderly; (c) anemias of unknown cause. The major biological questions concern the third category, which accounts for 14-17% of the anemias, and whether senescence itself contributes to anemia. Current opinion favors a diminished erythropoietic reserve with aging, but the data are inconsistent and the mechanism has not been established. It may be that cytokine modulation of erythropoiesis is abnormal. Some findings in unexplained anemia bear partial resemblance to the changes of anemia of chronic disease, suggesting the possibility that subtle unidentified inflammatory responses of unknown origin may be operative in many elderly people. Of the anemias of known cause that are especially common in the elderly, anemia of chronic disease is an important entity but is sometimes obscured or overlooked and its diagnosis rests on crude tests. Cobalamin deficiency is very common also, although most cases are mild and not accompanied by anem...Continue Reading

References

Mar 1, 1975·Journal of the American Geriatrics Society·Z Harant, J V Goldberger
Dec 1, 1992·American Journal of Hematology·K KarioR Asada
Oct 1, 1992·British Journal of Haematology·C AulW Schneider
Dec 1, 1992·Journal of the American Geriatrics Society·L C PennypackerS P Stabler
May 1, 1992·Journal of the American Geriatrics Society·M E SaliveH J Cohen
Jan 1, 1991·Journal of the American Geriatrics Society·J S PowersA Baer
Jun 1, 1987·Baillière's Clinical Haematology·A Kruger
Jun 30, 1988·The New England Journal of Medicine·J LindenbaumR H Allen
Feb 1, 1987·The American Journal of the Medical Sciences·N W Stead
Jul 1, 1987·Journal of the American Geriatrics Society·M L Timiras, H Brownstein
Sep 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·K S MattilaK Juva
Apr 1, 1974·The Journal of Clinical Investigation·S ZuckerR M Lysik
Jul 1, 1983·Journal of the American Geriatrics Society·P J GarryW C Hunt
Jan 1, 1981·American Journal of Hematology·D A LipschitzC Thompson
Nov 1, 1981·Mechanisms of Ageing and Development·T Vömel, D Platt
Mar 1, 1980·Journal of the American Geriatrics Society·T Kalchthaler, M E Tan
Sep 1, 1980·The American Journal of the Medical Sciences·M L Freedman, D L Marcus
Apr 1, 1995·Journal of the American Geriatrics Society·J Vijg, J Y Wei
Feb 1, 1995·Scandinavian Journal of Gastroenterology·G R CorazzaG Gasbarrini
Dec 1, 1994·Baillière's Clinical Haematology·A May, E Fitzsimons
Sep 1, 1993·Journal of Clinical Pathology·T L HolyoakeN P Lucie
Dec 1, 1993·Journal of the American Geriatrics Society·E JoostenW Pelemans
Jul 1, 1993·American Journal of Hematology·J NafzigerN Casadevall
Sep 1, 1995·Baillière's Clinical Haematology·R Carmel
May 27, 1996·Archives of Internal Medicine·R Carmel
Jul 1, 1997·Journal of the American Geriatrics Society·B J AníaL J Melton
Jul 1, 1997·European Journal of Clinical Nutrition·K E CharltonI Aronson
May 18, 1999·JAMA : the Journal of the American Medical Association·G J IzaksD L Knook
Jun 11, 1999·Experimental Gerontology·A Globerson
Sep 18, 1999·Lancet·J M LawrenceM A Umekubo
Apr 25, 2000·Annual Review of Medicine·R Carmel
Feb 15, 2001·Archives of Neurology·D DeleuA Louon
Jan 1, 1958·Journal of Clinical Pathology·A I SPRIGGS, R A SLADDEN
Jul 1, 1962·Journal of Clinical Pathology·A D HURDLE, A J ROSIN

❮ Previous
Next ❯

Citations

Apr 29, 2010·The Journal of Nutrition, Health & Aging·M A JohnsonUNKNOWN Georgia Centenarian Study
Jun 20, 2012·Journal of Hematology & Oncology·Cláudio César Monteiro de CastroRonald F Pinheiro
Oct 30, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Per Magne UelandSteinar Hustad
Sep 24, 2008·Seminars in Hematology·Ralph Carmel
Jul 18, 2008·La Presse médicale·Khalid SerrajEmmanuel Andrès
Nov 18, 2008·European Journal of Internal Medicine·Emmanuel AndrèsGeorges Kaltenbach
Jan 3, 2007·Experimental Hematology·Olga GurevitchShimon Slavin
Nov 9, 2007·Journal of Cellular Biochemistry·Hee-Young YangTae-Hoon Lee
Jan 12, 2007·Journal of the American Academy of Nurse Practitioners·C Michelle ThomasLeslie-Faith Morritt Taub
May 12, 2006·Journal of the American Geriatrics Society·Cinzia MaraldiUNKNOWN GIFA
Dec 21, 2012·Geriatrics & Gerontology International·Emmanuel AndrèsGeorges Kaltenbach
Jun 13, 2012·Geriatrics & Gerontology International·Itamar S SantosIsabela M Benseñor
Jun 27, 2006·Medical Hypotheses·Olga Gurevitch, Shimon Slavin
Feb 14, 2006·Blood Reviews·Richard EisenstaedtRichard C Woodman
Sep 26, 2015·Seminars in Hematology·M Domenica Cappellini, Irene Motta
Jun 14, 2013·Journal of the Royal Society of Medicine·Judith PartridgeJugdeep Dhesi
Feb 12, 2017·Geriatrics & Gerontology International·António Robalo NunesJosé Cortez
Feb 2, 2015·Revista brasileira de hematologia e hemoterapia·Fernando CalleraEvandro Secchi Rosa
Jul 1, 2006·Nature·Thomas A Rando
Apr 22, 2006·Journal of Neurosurgical Anesthesiology·Min LiThomas F Floyd
Feb 24, 2005·Current Opinion in Hematology·Richard WoodmanJack Guralnik
Apr 1, 2008·Nutrition Research and Practice·Hee-Seon Kim, Byung-Kook Lee
Apr 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Catharina LewerinDan Mellström
Oct 1, 2006·Expert Review of Pharmacoeconomics & Outcomes Research·Mei Sheng DuhPaul Greenberg
Nov 5, 2010·The Journal of Bone and Joint Surgery. American Volume·Jean WongFrances Chung
Feb 22, 2012·International Journal of Hematology·Robert M ShavelleDavid R Paculdo
Aug 30, 2007·Aging Clinical and Experimental Research·Richard D SembaJack M Guralnik
Jan 27, 2007·Aging Clinical and Experimental Research·Cinzia MaraldiStefano Volpato
Feb 18, 2003·Journal of the American Geriatrics Society·William B Ershler
Mar 19, 2020·Current Alzheimer Research·Chien-Tai HongLi-Nien Chien
Jun 9, 2020·Journal of Family Medicine and Primary Care·Charutha RetnakumarVijayakumar Krishnapillai
Jul 31, 2007·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·John ReedJerry Yee
Mar 2, 2012·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Amit Bhasin, Medha Y Rao
Jul 1, 2017·Nature Reviews. Disease Primers·Ralph GreenChittaranjan Yajnik

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Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.