Anemia and thrombocytopenia in patients undergoing chemotherapy for solid tumors: a descriptive study of a large outpatient oncology practice database, 2000-2007

Clinical Therapeutics
Ying WuLuba Nalysnyk

Abstract

This study was conducted to evaluate data on chemotherapy-associated anemia and thrombocytopenia, and cycle delays in patients with cancer in a community oncology practice. Data on adult patients (age > or =18 years) with cancer treated in outpatient oncology clinics throughout the United States between 2000 and 2007 were obtained from a large electronic medical records database. All types of cancer were included, although the focus was on solid cancers (ie, lung, breast, ovarian, head and neck, and colorectal cancers). Chemotherapy regimens were grouped from most to least toxic as follows: platinum-based, anthracycline-based, gemcitabine-based, taxane-based, and all other regimens. Anemia (defined as hemoglobin <11 g/dL), thrombocytopenia (defined as platelet count <150 x 10(9)/L), red blood cell (RBC) and platelet transfusions, and use of erythropoietin-stimulating agents (ESAs) were examined by tumor and regimen type. Cycle delays (>7 days) during chemotherapy were also evaluated. A total of 47,159 patients were included in the study (58.4% female; mean [SD] age, 60.76 [13.9] years). The most common cancer was breast cancer (19.5%), followed by non-small cell lung cancer (14.9%), colorectal cancer (11.9%), ovarian cancer (3....Continue Reading

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