PMID: 3747828Sep 1, 1986Paper

Anemia in alcoholics

Medicine
D Savage, J Lindenbaum

Abstract

In order to develop a diagnostic approach to the common problem of anemia associated with alcoholism, 121 chronic alcoholics admitted to a general medical service with a low hematocrit were evaluated. Multiple contributing causes of anemia were present in most patients. Megaloblastic marrow change was found in 33.9% of patients, sideroblastic change in 23.1%, absent iron stores in 13.2%, aggregated macrophage iron in 81.0%, and acute blood loss in 24.8%. The MCV was of little value in predicting the presence of megaloblastic change unless markedly elevated (greater than 110 fl). In 15 of 41 patients with megaloblastic marrow morphology (36.6%) the MCV was normal or low. Among 40 patients with MCV values between 100 and 110 fl, megaloblastic change was not present in the bone marrow smears of 24 (60.0%). Neutrophil hypersegmentation was 95% specific but only 78% sensitive for megaloblastic change; in contrast, the presence of macroovalocytosis was 90% sensitive but only 68% specific. Serum lactic dehydrogenase, plasma folate, and erythrocyte folate levels had such low sensitivities and specificities for megaloblastic change as to be of little predictive value. Hematologic responses to folic acid were often inadequate in patients...Continue Reading

Citations

Sep 5, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Gemma LewisAndrew Godkin
Apr 1, 1993·Journal of the American College of Nutrition·P J DrinkaJ S Goodwin
Oct 19, 2011·International Journal of Hepatology·Charles H Halsted, Valentina Medici
Aug 24, 2012·Journal of Blood Medicine·Shinsaku ImashukuShigehiro Kaneda
Feb 15, 2012·Advances in Nutrition·Charles H Halsted, Valentina Medici
Sep 23, 2010·Asian Journal of Transfusion Science· UpmaSubash Gupta
Apr 11, 2014·International Journal of Endocrinology and Metabolism·David Palacios-MartinezRaquel Asuncion Diaz-Alonso
Jul 25, 2000·Lancet·J L Spivak
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y Al-AbedR Bucala
Jul 30, 2014·Hematology/oncology Clinics of North America·Sylvia S Bottomley, Mark D Fleming
Feb 1, 1991·American Journal of Hematology·J P Jaffe, R F Schilling
Jun 1, 1992·The American Journal of the Medical Sciences·A A Mihas, M Tavassoli
Mar 9, 2010·Gastroenterología y hepatología·Nerea MuroJuan I Arenas
Jun 15, 2007·La Revue de médecine interne·J-S BladéJ-P Algayres
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Jaana LatvalaOnni Niemelä
Nov 13, 2007·American Journal of Hematology·Jesse Richman, Andrés Ferber
Nov 9, 2012·Molecular Nutrition & Food Research·Valentina Medici, Charles H Halsted
Jun 20, 2014·British Journal of Haematology·Vinod DevaliaUNKNOWN British Committee for Standards in Haematology
Sep 1, 1995·Baillière's Clinical Haematology·R Green
Mar 15, 2005·Clinics in Liver Disease·Michael D Voigt
Mar 15, 2005·Clinics in Liver Disease·Carroll M Leevy, Serban A Moroianu
Aug 20, 2008·Food and Nutrition Bulletin·Lindsay H Allen
Nov 21, 2017·Annals of Occupational and Environmental Medicine·Seng-Ho SongSang-Ha Lee
Mar 29, 2000·Hospital Medicine·N Younis, I F Casson
Mar 10, 2000·The American Journal of Gastroenterology·S FujimoriM Kobayashi
Oct 1, 1989·Alcoholism, Clinical and Experimental Research·H S Ballard
Apr 9, 2004·The Proceedings of the Nutrition Society·Gudrun PöschlHelmut K Seitz
Oct 26, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Charles H Halsted
Oct 4, 2013·European Journal of Gastroenterology & Hepatology·Abd Elrazek M A Abd ElrazekAhmed M El-Shamy
Mar 15, 2005·American Journal of Clinical Pathology·Monte S WillisSteven H Kroft
Mar 29, 2013·Journal of Nutritional Science and Vitaminology·Bogdan CylwikLech Chrostek
Feb 16, 2016·Cancer Cell International·Marco Allán Pérez-SolisArturo Aguilar-Rojas
Dec 19, 2016·BJPsych Open·Elisabeth Toverud LandaasJan Haavik

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