Anemia in infants with congenital hypothyroidism diagnosed by neonatal screening

Journal of Endocrinological Investigation
A FranzeseA Tenore

Abstract

Although anemia is a common finding in adult hypothyroid patients, there are no studies on anemia in hypothyroid infants. The aim of this study, therefore, was to review the hematologic status during the first year of life in 50 infants with congenital hypothyroidism detected through the regional neonatal screening program. The mean age at diagnosis was 23.7 +/- 6.5 days and treatment was initially begun with a mean L-thyroxine dose of 6.8 +/- 1.3 micrograms/kg/day. Clinical and haematological assessments were performed at diagnosis, 3, 6 and 12 months of age. The patients were divided in 2 groups based on whether T4 serum concentration at diagnosis was < 3 micrograms/dl (Group A) or > or = 3 micrograms/dl (Group B). Data for hemoglobin (Hb), hematocrit (Ht), red cells count (RCC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), serum iron and ferritin were expressed as Standard Deviation Score (SDS). Although at diagnosis the mean value of Hb-SDS, Ht-SDS and RCC-SDS were in the low-normal range in both groups, at 3 months of age the values in Group A (Hb -1.9 +/- 0.79; Ht -2.34 +/- 1.02; RCC -1.56 +/- 1.25) were significantly lower than in Group B (Hb -1.14 +/- 0.78, p < 0.005; Ht -1.59 +/- 0.94, p < 0.05; RC...Continue Reading

References

Jan 1, 1979·The Journal of Pediatrics·P R Dallman, M A Siimes
Sep 1, 1975·The Medical Clinics of North America·H G Fein, R S Rivlin
Feb 1, 1975·The Journal of Clinical Endocrinology and Metabolism·K C DasG K Rastogi
Jun 21, 1969·Lancet·C Wardrop, H E Hutchison
Nov 1, 1981·Clinical Pediatrics·J Y ChuA M Vernava

❮ Previous
Next ❯

Citations

Apr 2, 2009·Journal of Endocrinological Investigation·S Zahedi AslF Azizi
Nov 9, 2007·Annales d'endocrinologie·E LivadariuA Beckers
Oct 4, 2017·Blood·Ying ZhangJianguo Zhao
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·R R YammaniB Seetharam
Aug 28, 2007·Experimental Biology and Medicine·Fernanda S GravinaMarcos L S Perry
Sep 22, 2021·Journal of Developmental Origins of Health and Disease·Mayra Asas-Jinde, Fabricio González-Andrade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.