Jun 12, 2003

Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE)

Journal of the American College of Cardiology
Dariush MozaffarianWayne C Levy

Abstract

Our aim was to examine the relationships between serum hematocrit (Hct) and risk of all-cause mortality among patients with severe heart failure (HF). Anemia occurs with increased frequency in severe HF. However, few studies have examined the impact of anemia on mortality in this population. Using a prospective cohort design, we evaluated the relationships between baseline serum Hct and mortality among 1,130 patients with left ventricular EF <30% and New York Heart Association functional class IIIB or IV HF treated with angiotensin-converting enzyme inhibitors, diuretics, and digitalis. Mortality was ascertained by centralized adjudication. The mean Hct was 41.8% (range 25.4% to 58.8%). Over 15 months of mean follow-up, there were 407 deaths (29 per 100 person-years). After adjustment for potential confounders, those in the lowest quintile of Hct (range 25.4% to 37.5%) had a 52% higher risk of death (hazard ratio 1.52, 95% confidence interval 1.11 to 2.10), compared with the highest quintile (range 46.1% to 58.8%). Within the lowest quintile of Hct, each 1% decrease in Hct was associated with an 11% higher risk of death (p < 0.01), whereas within the four higher quintiles of Hct, Hct was not associated with total mortality. Eva...Continue Reading

Mentioned in this Paper

Severity of Illness Index
Incidence Studies
Survival Analysis
Digitalis preparation
Stroke Volume
Genus: Digitalis
Angiotensin-Converting Enzyme Inhibitors [MoA]
Heart Ventricle
Genus Anemia
Cause of Death

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