Anergy in memory CD4+ T cells is induced by B cells.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sarat K DalaiS Sadegh-Nasseri

Abstract

Induction of tolerance in memory T cells has profound implications in the treatment of autoimmune diseases and transplant rejection. Previously, we reported that the presentation of low densities of agonist peptide/MHC class II complexes induced anergy in memory CD4(+) T cells. In the present study, we address the specific interaction of different types of APCs with memory CD4(+) T cells. A novel ex vivo anergy assay first suggested that B cells induce anergy in memory T cells, and an in vivo cell transfer assay further confirmed those observations. We demonstrated that B cells pulsed with defined doses of Ag anergize memory CD4 cells in vivo. We established that CD11c(+) dendritic cells do not contribute to anergy induction to CD4 memory T cells, because diphtheria toxin receptor-transgenic mice that were conditionally depleted of dendritic cells optimally induced anergy in memory CD4(+) T cells. Moreover, B cell-deficient muMT mice did not induce anergy in memory T cells. We showed that B2 follicular B cells are the specific subpopulation of B cells that render memory T cells anergic. Furthermore, we present data showing that anergy in this system is mediated by CTLA-4 up-regulation on T cells. This is the first study to demo...Continue Reading

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Citations

Dec 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tony J KennaRaymond J Steptoe
Jun 18, 2015·Frontiers in Immunology·Marian Nassef Kadry Naguib RoufaielRaymond J Steptoe
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Jan 22, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Ting ChenJohn T Kung
Jan 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·John F RyanKari C Nadeau
Jun 15, 2017·Immunology and Cell Biology·Peta Ls ReevesRaymond J Steptoe
Nov 11, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Robin SchmitzJean Kwun
Mar 2, 2011·Immunology and Cell Biology·Sarat K DalaiScheherazade Sadegh-Nasseri
Nov 29, 2012·Autoimmunity·Kaiissar MannoorChing Chen
Apr 21, 2010·European Journal of Immunology·Mariam NasreenRaymond J Steptoe
Mar 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaiissar MannoorChing Chen
Jun 29, 2021·Frontiers in Immunology·Robin A WelshScheherazade Sadegh-Nasseri

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