Feb 13, 2016

Anesthesia Exposure and Risk of Dementia and Alzheimer's Disease: A Prospective Study

Journal of the American Geriatrics Society
Erin J Aiello BowlesSascha Dublin


To evaluate the associations between anesthesia and dementia or Alzheimer's disease (AD) risk using prospectively collected data. Cohort study. Community-dwelling members of the Adult Changes in Thought cohort aged 65 and older and free of dementia at baseline (N = 3,988). Participants self-reported all prior surgical procedures with general or neuraxial (spinal or epidural) anesthesia at baseline and reported new procedures every 2 years. People undergoing high-risk surgery with general anesthesia, other surgery with general anesthesia, and other surgery with neuraxial anesthesia exposures were compared with those with no surgery and no anesthesia. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia and AD associated with time-varying lifetime and recent (past 5 years) anesthesia exposures. At baseline, 254 (6%) people reported never having anesthesia; 248 (6%) had had one or more high-risk surgeries with general anesthesia, 3,363 (84%) had had one or more other surgeries with general anesthesia, and 123 (3%) had had one or more surgeries with neuraxial anesthesia. High-risk surgery with general anesthesia was not associated with greater risk of dementia (HR...Continue Reading

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Mentioned in this Paper

Senile Paranoid Dementia
Structure of Epidural Space
Familial Alzheimer Disease (FAD)
Surface of Neuraxis
Hematoma, Epidural, Spinal
Body Parts - Epidural
Alzheimer's Disease
Anesthesia Procedures
Malignant Hyperthermia Susceptibility Type 1

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