PMID: 9523823Apr 2, 1998Paper

Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor

Anesthesiology
J J QuinlanL L Firestone

Abstract

The mammalian gamma-aminobutyric acid type A (GABA(A)) receptor, a likely target of anesthetic action, exhibits remarkable subunit heterogeneity. In vitro expression studies suggest that there is subunit specificity to anesthetic responses at the GABA(A) receptor. The authors tested whether genetically engineered mice that lack the beta3 subunit of the GABA(A) receptor differed in their sensitivities to several general anesthetic agents. Median effective concentrations for loss-of-righting reflex and tail clamp/withdrawal for enflurane and halothane were determined in mice with and without the beta3 gene and gene product. Sleep time was measured after intraperitoneal injection of pentobarbital, ethanol, etomidate, and midazolam. Null allele mice (beta3 -/-) did not differ from wild-type mice (beta3 +/+) in the obtunding response to enflurane and halothane but were significantly more resistant to enflurane (null allele half-effect concentrations [EC50] of 2.59 +/- 0.10 vs. wild-type EC50 of 2.06 +/- 0.12 atm %, P < 0.001) and halothane (null allele EC50 of 1.73 +/- 0.04 vs. wild-type EC50 of 1.59 +/- 0.05 atm %, P = 0.01) as determined by tail clamp response. Wild-type and null allele mice exhibited divergent responses to other ...Continue Reading

References

Mar 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R W Olsen, A J Tobin
Jan 1, 1987·Anesthesiology·J K AlifimoffK W Miller
Sep 1, 1967·Anesthesiology·J H EiseleM Muallem
Jun 1, 1981·Anesthesia and Analgesia·J E DeadyB D'Aoust
Jan 1, 1981·British Journal of Anaesthesia·D D Koblin, J E Deady
Nov 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R A HarrisT K Machu
Nov 1, 1994·Anesthesia and Analgesia·J J QuinlanL L Firestone
Apr 1, 1993·Anesthesiology·D L TanelianM B MacIver
Feb 1, 1996·Anesthesia and Analgesia·L KandelE I Eger
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·G E HomanicsR W Olsen

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Citations

Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·M D Krasowski, N L Harrison
Mar 31, 2010·Pflügers Archiv : European journal of physiology·Aristea S Galanopoulou
Dec 22, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Berthold DrexlerUwe Rudolph
May 26, 2005·European Journal of Pharmacology·Sachar LambertUwe Rudolph
Jan 16, 2003·Physiology & Behavior·Gregg E HomanicsPei Tang
May 26, 1999·Pharmacology, Biochemistry, and Behavior·G E HomanicsL L Firestone
Apr 21, 1999·Brain Research. Brain Research Reviews·A K Mehta, M K Ticku
Apr 3, 2001·Trends in Pharmacological Sciences·U RudolphH Möhler
Dec 22, 1999·Trends in Pharmacological Sciences·D BelelliJ J Lambert
Jul 16, 1999·Neurochemistry International·S J Mihic
Aug 24, 2004·Nature Reviews. Neuroscience·Uwe Rudolph, Bernd Antkowiak
May 23, 2003·The New England Journal of Medicine·Jason A CampagnaStuart A Forman
Nov 15, 2001·Regional Anesthesia and Pain Medicine·D L Hammond
Jul 12, 2008·International Anesthesiology Clinics·Stuart A Forman, Victor A Chin
Sep 12, 2006·Addiction Biology·John C CrabbeGeorge F Koob
Nov 11, 2011·The Journal of Pharmacology and Experimental Therapeutics·W David JohnsonR Adron Harris
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·T YamakuraR A Harris
Aug 29, 2002·Anesthesia and Analgesia·Joseph J QuinlanGregg E Homanics
Dec 31, 2002·Anesthesia and Analgesia·Yi ZhangJames M Sonner
Jun 24, 2003·Anesthesia and Analgesia·Tetsuhiro TakeiTsutomu Tanabe
Jul 30, 2004·Anesthesia and Analgesia·Yi ZhangR Adron Harris
Sep 24, 2004·Anesthesia and Analgesia·Takefumi InadaKoh Shingu
Aug 21, 2008·Anesthesia and Analgesia·Edmond I EgerJames M Sonner
Oct 19, 2000·Journal of Basic and Clinical Physiology and Pharmacology·M Perouansky, R A Pearce
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roman M LazarenkoDouglas A Bayliss
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·R M MihalekG E Homanics
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·P NageleC M Crowder
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B van SwinderenC M Crowder
Nov 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·M WallnerR W Olsen

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