PMID: 1119711Apr 1, 1975

Anesthetic biotransformation and renal function in obese patients during and after methoxyflurane or halothane anesthesia

Anesthesiology
S R YoungJ A Madura

Abstract

Anesthetic biotransformation and renal function were studied in obese adult patients (148 plus or minus 8 kg; mean plus or minus SE) anesthetized for three hours with 60 per cent nitrous oxide plus either methoxyflurane or halothane for elective jejunoileal small-bowel-bypass operations. There was no evidence of persistent renal dysfunction in any patient postoperatively, but serum osmolality was elevated 72 hours after methoxyflurane anesthesia. Urine concentrating ability was not determined. Peak serum ionic fluoride concentration was 55.8 plus or minus 5.8 muM/1 two hours after discontinuation of methoxyflurane. Urinary ionic fluoride and oxalate excretions increased postoperatively. Compared with previously reported data from nonobese patients, serum ionic fluoride concentrations in obese patients increased more rapidly during methoxyflurane anesthesia and peaked higher and sooner after discontinuation of methoxyflurane. The peak serum ionic fluoride concentration was 10.4 plus or minus 1.5 muM/1 at the conclusion of halothane anesthesia, significantly more than the corresponding value in nonobese patients. Intraoperative liver biopsies from 23 of 27 patients showed moderate to severe fatty metamorphosis. Fatty liver infilt...Continue Reading

Citations

Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J R KambamB V Sastry
Sep 1, 1984·Brain Research Bulletin·P S Lasiter, J Garcia
Nov 21, 1985·The New England Journal of Medicine·G FarrellM Murray
Jan 1, 1978·Acta Anaesthesiologica Scandinavica·M Andreen, L Irestedt
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·S Sharifi, N Vesal
Mar 1, 1989·Postgraduate Medical Journal·D RosenakR Orda
Jan 1, 1982·Quarterly Reviews on Drug Metabolism and Drug Interactions·J L PlummerP Hall
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·L Singer, R Ophaug
Jan 1, 1993·Journal of Clinical Anesthesia·G A Trempy, P Rock
Apr 6, 2005·Journal of Clinical Anesthesia·Andrea Casati, Marta Putzu
Nov 15, 1977·Biochemical Pharmacology·B R Brown, I G Sipes
Jun 1, 1988·The American Journal of Medicine·D E Salazar, G B Corcoran
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·P B ChristoffW J Jusko
Nov 1, 1983·Anaesthesia and Intensive Care·M J CousinsJ L Plummer
May 1, 1980·Anaesthesia and Intensive Care·B J Pollard, J Coombs

Related Concepts

Adjuvants, Anesthesia
Insufflation Anesthesia
Needle Biopsy Procedure
Metabolic Biotransformation
Steatohepatitis
Fluorides
Narcotan
Kidney
Kidney Function Tests
Liver

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.