PMID: 1119711Apr 1, 1975

Anesthetic biotransformation and renal function in obese patients during and after methoxyflurane or halothane anesthesia

S R YoungJ A Madura


Anesthetic biotransformation and renal function were studied in obese adult patients (148 plus or minus 8 kg; mean plus or minus SE) anesthetized for three hours with 60 per cent nitrous oxide plus either methoxyflurane or halothane for elective jejunoileal small-bowel-bypass operations. There was no evidence of persistent renal dysfunction in any patient postoperatively, but serum osmolality was elevated 72 hours after methoxyflurane anesthesia. Urine concentrating ability was not determined. Peak serum ionic fluoride concentration was 55.8 plus or minus 5.8 muM/1 two hours after discontinuation of methoxyflurane. Urinary ionic fluoride and oxalate excretions increased postoperatively. Compared with previously reported data from nonobese patients, serum ionic fluoride concentrations in obese patients increased more rapidly during methoxyflurane anesthesia and peaked higher and sooner after discontinuation of methoxyflurane. The peak serum ionic fluoride concentration was 10.4 plus or minus 1.5 muM/1 at the conclusion of halothane anesthesia, significantly more than the corresponding value in nonobese patients. Intraoperative liver biopsies from 23 of 27 patients showed moderate to severe fatty metamorphosis. Fatty liver infilt...Continue Reading


Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J R KambamB V Sastry
Sep 1, 1984·Brain Research Bulletin·P S Lasiter, J Garcia
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Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·S Sharifi, N Vesal
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Related Concepts

Adjuvants, Anesthesia
Insufflation Anesthesia
Needle Biopsy Procedure
Metabolic Biotransformation
Kidney Function Tests

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